Since I don't like attachments, I will first iterate the title of the
attached publication:
"Traditional Biomolecular Structure Determination by NMR Spectroscopy
Allows for Major Errors "
It immediately reminded me of an older one (ehm .. one author in
common!), addressed at that time mostly to crystallographers:
"Errors in protein structures." (Nature 1996)
... and I am afraid that the authors were right in both cases (they
did not make many friends publishing these though)
Crystallographers learned from that paper back then. And the
participation of NMR spectroscopists on the 2006 paper
implies they are also learning ;-)
A.
On Nov 14, 2008, at 6:34, Bernhard Rupp wrote:
>> wondering what people think of this.
>
> Very funny.
>
> But no kidding, Richard Dickerson, the pioneer of DNA crystallography,
> comes from your institution. For DNA, NMR has the benefit of readily
> identifying intercalations in short oligomers etc w/o agony of
> crystallizing.
>
> For others, pls see attached. As a physical principle, spectroscopic
> methods do not deliver atomic resolution structures, but a set of
> inferences that may or may no be compatible with a molecular model.
>
> BR
> <Nabuurs_2006_PLOS_biomolecular_structure_NMR_errors.pdf>
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