Dear Adam,
Although we are on the other side of the world we have detected a similar problem
moving from the old to the new Siemens Centaur Free T4 assays (FrT4 to FT4). Our
negative bias is about 1.5 pmol/L which is not much on an indiviidual basis but
would create a significant increase in asterisks on the low side.
Regards,
Graham
Graham Jones
Staff Specialist in Chemical Pathology
St Vincent's Hospital, Sydney
Ph: (02) 8382-9160
Fax: (02) 8382-2489
>>> "Gerrard Adam (agerrard)" <[log in to unmask]> 21/11/2008 2:22 am >>>
Dear all,
We have recently moved to the 'new' Siemens Centaur fT4 assay "which has
improved reagent stability... but does not affect results".
Unfortunately we took their word for this, however whilst our IQC has
not been at all affected, we have found that our patient results have
dropped by ~3.7 pmol/L (constant bias), which is causing havoc. We have
been told there is no more of the old reagent available.
The latest NEQAS return (321) included the following statement "the new
Free T4 assay does appear to be producing lower numerical values, but
there appears to be continuum of results rather than two distinct
populations at present".
I was wondering whether other users of Lot Number 1 had seen quite such
a significant change? If other users who have had a problem could please
let me know to what extent their results have changed I would be very
grateful, and I would also suggest that anyone else about to make the
change does a quick comparison first...
Regards,
Adam
Adam Gerrard
Nottingham University Hospitals
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