Dear All,
does someone know the proper reference of this L. Pauling statement?
"Although the hydrogen bond is not strong it has great significance in
determining the properties of substances. Because of its small bond energy
and the small activation energy involved in its formation and rupture, the
hydrogen bond is especially suited to play a part in reactions occurring at
normal temperatures. It has been recognised that hydrogen bonds restrain
protein molecules to their native configurations, and I believe that as the
methods of structural chemistry are further applied to physiological
problems it will be found that the significance of the hydrogen bond for
physiology is greater than that of any other single structural feature".
It is quoted by Perutz but no ref
Thx, br
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