I have a question about multiplying jacobian determinants by the tissue
From what I understand the jacobian determinants are obtained from the
deformation fields. If the deformation fields are relative to the source
image (not relative to the template) then jacobian determinants will also
be relative to the source as well. So if a voxel in the source image had
its voxel volume expanded by 2 relative to the target then the value at
that voxel in the jacobian determinant will be 2.
If we then want to apply modulation then should'nt we multiply by 1 over
the jacobian determinants (at each voxel) to preserve volume information
rather than by the jacobian determinant itself?