Dear All :
I am studying a mutant protein related with a disease. In the mutated
version of this protein there is an alpha helical segment that protrudes
into the solvent. This alpha helix is not present in the wild type
protein.
I was wondering if any of you know some papers in which the "toxicity" of
this exposed hydrophobic alpha helices is reported. I have some
cross-references in which the authors said that some of these exposed
hydrophobic alpha helical fragments could recrute cellular chaperones
(Hsp70 and Hsp90).
Any help will be appreciated
All the best
Francisco
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Francisco J. Enguita, Ph.D.
Host-pathogen Interactions Group
Macromolecular Crystallography Laboratory
ITQB
EAN, Av. da República
2781-901 Oeiras
Portugal
Phone : +351-21-4469663
Fax : +351-21-4433644
E-mail : [log in to unmask]
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