> Dear SPM users,
> I have compared gray matter volumes of MCI patients with that of
> healthy controls using SPM5 (voxel based morphometry).
> The MCI patients show grey matter loss in some regions important for
> episodic memory retrieval.
> Now I would like investigate, whether there is a correlation between
> the performance in word list recall and grey matter loss.
> Is there a way to do such an analysis in SPM5? If the answer is yes –
> how does it work? Is there any users guide explaining the steps (since
> I am not a very experienced SPM user)?
Well using the multiple regression design could for instance not only
test the difference between groups (regressor 1 and -1 for control / MCI
- simply test with 1 in the contrast manager) but also the correlation
within each group and between groups (regressor xxxx0000 for controls
for instance and 0000xxxx for MCI - then 10 = correlation in controls,
01 correlation in MCI and 1-1 controls>MCI). For more information on VBM
and possible things to look at I would suggest first looking at the VBM5
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