Our paper describes why PTH is not a good index of vitamin D status
Patel S, Hyer S, Barron J 2007
Glomerular filtration rate is a major determinant of the relationship between 25-hydroxyvitamin D and parathyroid hormone
Calcified Tissue International.80, 221-226.
Jeff
Dr Jeffrey Barron
Consultant Chemical Pathologist
Director SW Thames Regional Newborn Screening
St Helier Hospital
Carshalton
Surrey SM5 1AA
UK
Tel UK 20 8296 2660
Fax UK 20 8641 2633
[log in to unmask]
>>> Victoria Clough <[log in to unmask]> 03/17/08 1:30 pm >>>
We have noticed a significant increase in the number of requests we are
receiving for 25OHD and are trying to establish whether it is always
necessary to measure 25OHD itself or if PTH can be used as a first line
test, with 25OHD being measured only if the PTH is raised. I've come
across a couple of papers which recommend the above approach but have also
read several which suggest that PTH is no substitute for 25OHD as it can be
normal in vitamin D deficiency and shows poor correlation with 25OHD, with
the relationship between the 2 analytes varying with age.
It would be useful to know the approach taken by other labs and I'd be
grateful for any references which decisions have been based on.
Thank you
Victoria Clough
Pre-Registration Clinical Biochemist
King George Hospital, Goodmayes
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BEGIN:VCARD
VERSION:2.1
X-GWTYPE:USER
FN:Barron, Jeffrey
TEL;WORK:020 8296 2660
ORG:;Chemical Pathology
EMAIL;WORK;PREF;NGW:[log in to unmask]
N:Barron;Jeffrey
TITLE:Consultant
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