Here are two references. One with the theory and one with an example.
Pogue JM, Yusuf S. Cumulating evidence from randomized
trials: utilizing sequential monitoring boundaries for
cumulative meta-analysis. Control Clin Trials 1997; 18:
580–593.
Devereaux PJ, BeattieWS, Choi PT, Badner NH,
Guyatt GH, Villar JC et al. How strong is the evidence for
the use of perioperative beta blockers in non-cardiac surgery?
Systematic review and meta-analysis of randomised
controlled trials. BMJ 2005; 331: 313–321
Pablo
Pablo Alonso Coello
Centro Cochrane Iberoamericano
Hospital de la Santa Creu i Sant Pau
C/Sant Antoni Mª Claret 171
(08041) Barcelona
telf: + 34 93 291 95 27
Fax: +34 93 291 95 25
>>> "Ahmed M. Abou-Setta, M.D." <[log in to unmask]> 29/2/2008 12:47
>>>
Dear All,
Hope all is well. Over the years the issue regarding the number of
included studies, total number of included participants and sample size
(power) of a meta-analysis has been debated. Some have insisted that it
can and should be done, while others have said that it is not possible.
I would like to hear the opinion of anyone who has knowledge of this
subject, and I would love some references for future debates.
Thank you for your time and consideration.
Please accept my regards.
Sincerely,
Ahmed M. Abou-Setta, MD
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