Hello:
This is my first time designing matrix and I hope I could get some feedback and suggestion. It
will be very much appreciated.
I want to compare control vs. patient group and see if there is any brain region showing gray
matter reduction that can be explained by effective regressor (EV3: demeaned control group
abuse score. EV4: demeaned patient group abuse score) after regress out confounds (EV 5:
demeaned control group age, EV 6: demeaned patient group age).
Example:
Abuse score for control: 5 7 12
Abuse score for patient: 15 10 20
Age for control: 10 12 14
Age for patient: 12 14 16
Design Matrix:
EV1 EV2 EV3 EV4 EV5 EV6
1 0 -3 0 -2 0
1 0 -1 0 0 0
1 0 4 0 2 0
0 1 0 0 0 -2
0 1 0 -5 0 0
0 1 0 5 0 2
ortho EV3 wrt to EV 5
ortho EV4 wrt to EV 6
Contrast:
0 0 1 -1 0 0
0 0 -1 1 0 0
Will this design be able to answer my question?
Kindly advise.
Thank you very much.
Yi-Shin
|