PhD Scholarship - Statistical Genetics/Bioinformatics - QIMR, Brisbane,
Australia.
Queensland Institute of Medical Research (QIMR), Brisbane, Australia /
University of Queensland, Brisbane, Australia.
Primary supervisor: Dr Stuart Macgregor
Applications: open until position filled. To apply, send CV to
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Stipend: Fully funded stipend available for 'home' applicant (AUS$20K per
annum tax free, rising to AUS$25K subject to satisfactory progress). 'home'
applicant means Australian/New Zealand citizens/permanent residents.
International students are still eligible for AUS$20K stipend but may need
to pay additional tuition fees – please contact [log in to unmask]
for further details. Reasonable relocation expenses available. Funding is
tenable for 3 years.
Title: Statistical and computational methods for gene mapping
Description:
The project will focus on statistical and computational methods for locating
disease susceptibility genes. This will be based mainly on genome wide
association approaches with a particular emphasis on an approach known as
DNA pooling. The DNA pooling approach greatly decreases the cost of genome
wide association approaches but brings with it a new set of computational
and statistical challenges. There will also be scope in the project for work
on more general approaches utilising genomewide data, including work on gene
expression and related bioinformatics. The project will address a wide range
of disease phenotypes and as such can be readily tailored to accommodate the
specific interests of the student.
The student will be based in the genetic epidemiology department (
http://genepi.qimr.edu.au/ ) at QIMR, Brisbane. QIMR is one of the largest
medical research institutes in the southern hemisphere. The genetic
epidemiology department is the single largest grouping at QIMR and employs
several internationally renowned researchers in the field.
References:
S. Macgregor, P.M. Visscher, G. Montgomery. 2006. Analysis of pooled DNA
samples on high density arrays without prior knowledge of differential
hybridization rates. Nucleic Acids Research, 34(7):e55.
S. Macgregor. 2007. Most pooling variation in array based DNA pooling is
attributable to array error rather than pool construction error. European
Journal of Human Genetics 15: 501-504.
S. Macgregor, Z.Z. Zhao, A. Henders, N.G. Martin, G.W. Montgomery, P.M.
Visscher, 2008. Highly cost efficient genome wide association studies using
DNA pools and dense SNP arrays, in press, Nucleic Acids Research.
Research Areas: Statistical Genetics, Genetic Epidemiology, Bioinformatics.
Suitable first degree/background: Applicants must hold at least a second
class honours degree and/or relevant Masters degree in statistics,
biological sciences, mathematics, computer science or a related field.
Knowledge of genetics advantageous but not essential. Biological sciences
applicants must be able to demonstrate some knowledge of statistics.
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Dr Stuart Macgregor
Genetic Epidemiology
Queensland Institute of Medical Research
Post Office, Royal Brisbane Hospital
300 Herston Road
Brisbane 4029, Australia
tel. +61 7 3845 3563
fax. +61 7 3362 0101
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