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COMPUTATIONAL AND CLINICAL TRIALS: ***EXTENDED DEADLINE 31st JANUARY 2008***

Dear Colleague,
 
when corresponding with interested potential authors we were asked to extend
the deadline such that they could use the turn of the year to finish their
manuscript. Therefore the editorial team decided to extend the deadlines for
all as follows:

	New deadline for submission: 31 January 2008
        Notification of decision:    31 March 2008


Below you will find the respectively updated call for papers.


With all the best wishes for the Season and a Happy New Year

Sincerely yours 

Lutz Edler, Jae Won Lee, Martina Mittlböck, Joyce Niland and Norbert Victor


========================== UPDATED DECEMBER  17 ==========================
CALL FOR PAPERS
COMPUTATIONAL STATISTICS & DATA ANALYSIS Special Issue on COMPUTATIONAL AND
CLINICAL TRIALS http://www.elsevier.nl/locate/csda

Guest Editors:
    Lutz Edler, Jae Won Lee, Martina Mittlböck, Joyce Niland and
    Norbert Victor

We are inviting submissions for the 1st special issue of Computational
Statistics and Data Analysis that address statistical methods and
computational data analysis approaches in the design and/or analysis of
clinical studies, covering both, the pharmaceutical clinical trials for the
detection and characterization of better treatments as well as the
explorative clinical studies for the understanding of diseases and their
treatment.

With the appearance of larger data sets both in terms sample size and in
terms of number of patients' characteristics measured the need of new
appropriate and efficient computational methods and data analysis approaches
has become urgent during the last decade. Whereas extraordinary efforts and
large investments were devoted to increase the quality of clinical data much
less has been invested in computational statistics methods fit for clinical
research purpose.

The special issue will include:

* design and data analysis for Phase I,II, III trials
* pharmacokinetics and dose finding studies
* exploratory analysis and prognostic factors
* cross-over studies
* diagnostic studies and biomarker evaluation
* longitudinal data analyses and safety evaluation
* pharmacogenetic and pharmocogenomic data
* predictive factors and medical decision making
* treatment allocation and adaptive designs
* meta analyses and interpreting clinical trial results
* Bayesian methods and population models
* medical informatics and bioinformatics
* competing risk and multistate models
* disease modelling and public health

For this special issue we are now soliciting papers that address statistical
and computational aspects of the design or analysis of clinical studies.
Theoretical papers or papers with simulation as the main contribution are
not suitable for the special issue. However overviews are welcome if they
provide new and original work able to promote research.

In addition, the journal offers authors the possibility to enhance their
articles by including data sets along with the online article.
These files will appear embedded in the article on ScienceDirect at
www.sciencedirect.com/science/journal/01679473.  The files will be freely
available at this site. Copyright of the files will remain with the authors
and their use will require the citation of the related article (journal,
author, title and date of the publication).  No liability is assumed by the
contributors, the publisher, or the IASC.

Submission must contain original unpublished work and both, a computational
and a medical or clinical component, possibly combined with a substantive
application. This can include comprehensive and intellectually synthetic
review papers that is not being submitted for publication elsewhere.

The deadline for submissions is 31 January 2008. Notification of decisions
will be given by end of March (31 March, 2008). Authors who are uncertain
about the suitability of their papers should contact one of the special
issue editors. All submissions must contain original unpublished work not
being considered for publication elsewhere.

Papers should be submitted using the Elsevier Electronic Submission tool
EES: http://ees.elsevier.com/csda In the EES please chose the special issue
on "Computation and Clinical Trials".

Submissions will be refereed according to standard procedures for
Computational Statistics and Data Analysis (CSDA). Information about the
journal can be found at http://www.elsevier.com/locate/csda. The CSDA is
indexed in Science Citation Index (Web of Science).


The special issue editors:

Lutz Edler
Department of Biostatistics, German Cancer Research Center, Heidelberg, Germany
E-mail: [log in to unmask]

Jae Won Lee
Department of Statistics, Korea University, Seoul, South Korea
E-mail: [log in to unmask]

Martina Mittlböck
Core Unit for Medical Statistics and Informatics, Medical University of
Vienna, Vienna, Austria
E-mail: [log in to unmask]

Joyce Niland
City of Hope Comprehensive Cancer Center, Division of Information Sciences
Duarte, California, USA
E-mail: [log in to unmask]

Norbert Victor
Institute of Medical Biometry and Informatics, University of Heidelberg, Germany
E-mail: [log in to unmask]