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ACB-CLIN-CHEM-GEN  December 2007

ACB-CLIN-CHEM-GEN December 2007

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Subject:

Re: EDTA as in vitro anticoagulant

From:

Jeffrey Davies <[log in to unmask]>

Reply-To:

Jeffrey Davies <[log in to unmask]>

Date:

Fri, 28 Dec 2007 10:40:34 +0000

Content-Type:

text/plain

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Parts/Attachments

text/plain (82 lines)

L. S. Sacker, K. E. Saunders, Beryl Page, and Margaret Goodfellow.
DILITHIUM SEQUESTRENE AS AN ANTICOAGULANT J Clin Pathol. 1959 May;
12(3): 254–257 is not as early as your reference, but they cite
Proescher F. (1951) Proc Soc Exp Biol and Med (NY) 76, 619 together with
Hadley & Larson for the use of disodium EDTA as an anticoagulant for
haematology. Sacker's interesting proposal was the use of LiEDTA for
both haematological and common biochemical analyses. Hoch & Chanutin's
paper "Effects of anticoagulants on serum and plasma" (concerning
protein electrophoresis) was published in the Journal of Biological
Chemistry in 1952 and they also cited Proescher's 1951 paper.   
But EDTA was first synthesised in the late 1930's so there may be still
earlier references out there!
Happy New Year,
Jeff Davies
Bradford Royal Infirmary

>>> BRECHOT <[log in to unmask]> 25/12/2007 22:12:27 >>>
HADLEY (G Gordon) & LARSON (Norman L) - Use of sequestrene as an  
anticoagulant - Am J Clin Pathol, 1953, 23: 613-618

Merry Christmas !!

JF Brechot

------------------------------
Having read "The role of EDTA as in vitro anticoagulant for  
diagnostic purposes" (Clin Chem Lab Med 2007;45:565) I can not resist 

asking you about the first-ever appearance of EDTA as in vitro  
anticoagulant in the scientific literature.

I do hope that some of the older (sorry: more experienced) fellows  
still have (old-fashioned ?) notes on that ...

Michael Steiner

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