Hi Shaquanda,
> the issue of spacial smoothing for irregular volumes
If you are interested in data that are irregular in the sense of "not
on a grid" (rather than just on an anisotropic grid) then you might be
interested in some of the literature for surface-based analysis (of
e.g. fMRI or cortical thickness), e.g.
http://linkinghub.elsevier.com/retrieve/pii/S1053811904007542
(and references within)
Best,
Ged
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