Presently, a PhD position is open on the project “The mechanics of
molecular machines”.
Project: It is tempting to consider molecular machines as nanoscale
versions of their macroscopic analogues. However, many macroscopic
mechanical concepts no longer apply at a molecular level. For instance, the
concept of friction becomes meaningless for a molecular machine, since the
size of the solvent molecules causing the friction is comparable to that of
the machine itself. Also, a molecular machine experiences interactions with
the surrounding solvent that in many cases are comparable to the force
driving the machine. This will give rise to a certain amount of
unpredictability in the motion of molecular machines. At present, the
nature of the mechanics of molecular machines is largely unknown. At the
University of Amsterdam, we experimentally investigate the mechanical
behavior of prototypical molecular machines. In this project, financed by
the Stichting voor Fundamenteel Onderzoek der Materie (FOM), we have a
fully funded PhD position available.
Job description: The candidate will carry out and interpret experiments in
which the operation of a molecular machine is triggered by means of a UV
trigger pulse, and the mechanical motions are followed in real time by
means of time-resolved one- and two-dimensional infrared spectroscopy. In
this way, it is possible to construct "movies" of working molecular
machines, and to study their mechanical motions directly. The time scales,
velocities and potential-energy landscapes involved in the motions will be
determined, and on a more fundamental level, we want to find out to what
extent the motion of molecular machines is deterministic. The candidate
will also explore ways of modifying, and in particular optimizing, the
predictability of the motion (for instance by varying the design of the
machine), and investigate if it is possible to 'kick-start' a molecular
machine by means of optically induced breaking of hydrogen bonds.
The project will be carried out at the University of Amsterdam under the
supervision of dr. Sander Woutersen and prof. Wybren Jan Buma. We are
looking for an enthusiastic candidate with a strong background in
experimental physics or physical chemistry that has started his/her
academic studies not later than 7 years ago. Experience with lasers is an
advantage but not explicitly required. Interested candidates can apply by
sending their CV and the names of 2 references to either Dr. S. Woutersen
or Prof. W.J. Buma.
For further information please contact:
Dr. Sander Woutersen, E-mail: [log in to unmask] , Phone:+31-20-525
7091
Prof. Wybren Jan Buma, E-mail: [log in to unmask] , Phone:+31-20-525 6973/6421
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