Dear all,

Please circulate this job opening to anyone you think might be interested.

Thanks,
 Flora 


 

Post-Doctoral Research Associate: Virus Structure and Function

 

The Spallation Neutron Source at Oak Ridge National Laboratory (http://www.sns.gov) and the Center for Structural Molecular Biology (http://www.csmb.ornl.gov), in collaboration with the North Carolina State University Department of Molecular and Structural Biochemistry (http://biochem.ncsu.edu <http://biochem.ncsu.edu/> ) have an opening for a Post-Doctoral research associate.

We seek a Biophysicist/Biochemist or Physicist to work on Small Angle Neutron Scattering (SANS) and neutron reflectivity analysis of virus structure and function.

Arthropod borne viruses (arboviruses) are transmitted by blood sucking insects and cause some of the most devastating diseases known to human and veterinary medicine. Sindbis virus is prototypic of the arboviruses. Its structure is complex, comprising two nested icosahedral shells separated by a lipid membrane that protects a core of single-stranded RNA. Cellular interaction and infection involves dramatic reorganization of the virus surface and interior and in the appearance of the lipid bilayer.  These transitions can be duplicated by exposure to acidic pH. The aim of the project is to characterize these dynamic changes in solution and during membrane surface interactions with a series of neutron scattering and reflectometry experiments that employ contrast variation and modeling. The ultimate goal is to elucidate the infection mechanism of Sindbis across several levels of complexity.

The candidate should be proficient in conducting all aspects of experimental scattering and analysis, data reduction and modeling. Previous work in either neutron or X-ray scattering is desirable. Contacts: Dr. Flora Meilleur, email: [log in to unmask] <mailto:[log in to unmask]>  (http://biochem.ncsu.edu/faculty/meilleur/meilleur.html); Dr. Dennis Brown, email: [log in to unmask] (http://biochem.ncsu.edu/faculty/brown/brown.htm)

 
 

How to Apply:  

Qualified applicants may apply online at https://www2.orau.gov/ORNL_POST/. AlL applicants will need to register before they can begin the online application.   All applications must be received by December 20, 2007. For complete instructions, on how to apply, please see the instructions at http://www.orau.gov/orise/edu/ornl/ornl-pdpm/application.htm <http://www.orau.gov/orise/edu/ornl/ornl-pdpm/application.htm> . When applying for this position, please reference the position title and number. This appointment is offered through the ORNL Postdoctoral Research Associates Program and is administered by Oak Ridge Associated Universities (ORAU). This appointment is open to all qualified U.S. and non-U.S. citizens without regard to race, color, age, religion, sex, national origin, physical or mental disability, or status as a Vietnam-era veteran or disabled veteran. 

 

 

Flora Meilleur
 
Department of Molecular & Structural Biochemistry, North Carolina State University
& the Spallation Neutron Source, Oak Ridge National Laboratory
 
Phone: (865) 576-5230