JiscMail Logo
Email discussion lists for the UK Education and Research communities

Help for ACB-CLIN-CHEM-GEN Archives


ACB-CLIN-CHEM-GEN Archives

ACB-CLIN-CHEM-GEN Archives


ACB-CLIN-CHEM-GEN@JISCMAIL.AC.UK


View:

Message:

[

First

|

Previous

|

Next

|

Last

]

By Topic:

[

First

|

Previous

|

Next

|

Last

]

By Author:

[

First

|

Previous

|

Next

|

Last

]

Font:

Proportional Font

LISTSERV Archives

LISTSERV Archives

ACB-CLIN-CHEM-GEN Home

ACB-CLIN-CHEM-GEN Home

ACB-CLIN-CHEM-GEN  October 2007

ACB-CLIN-CHEM-GEN October 2007

Options

Subscribe or Unsubscribe

Subscribe or Unsubscribe

Log In

Log In

Get Password

Get Password

Subject:

Re: Profound hypomagnesaemia

From:

EDMUND LAMB <[log in to unmask]>

Reply-To:

EDMUND LAMB <[log in to unmask]>

Date:

Tue, 2 Oct 2007 08:19:54 +0100

Content-Type:

text/plain

Parts/Attachments:

Parts/Attachments

text/plain (156 lines)

Has omeprazole use been excluded? There have been two published case
reports of this association with hypomagnesaemia and we have seen two
cases locally that we hope to publish.

See:

Epstein M, McGrath S, Law F. Proton-pump inhibitors and hypomagnesemic
hypoparathyroidism. N Engl J Med 2006;355:1834-6.

regards
Edmund

-----------------------------------------------------------------------------------------------------------
Dr Edmund Lamb PhD FRCPath
Consultant Clinical Scientist (Biochemistry) and Head of Department
Department of Clinical Biochemistry,
East Kent Hospitals NHS Trust,
Kent and Canterbury Hospital,
Ethelbert Road, Canterbury,
Kent CT1 3NG, UK
Tel: (44) 01227-766877 extn 74736
Fax: (44) 01227-783077

>>> Ian Young <[log in to unmask]> 10/01/07 9:53 pm >>>
Profound hypomagnesaemiaDear all

I look after two adult patients with significant recurrent
hypomagnesaemia of this kind.  I think that the cause is a selective
renal Mg leak in both cases.  The TRPM6 cases have a renal leak as well
as the GI problem (see Nature Genetics  31, 171 - 174 (2002).  The
urinary Mg results are difficult to interpret, as renal Mg absorption
may occur once serum Mg drops below a threshold value.  The Nature paper
above shows results of an Mg loading test which would be a useful
investigation if you wanted to investigate further. (Coincidentally I
saw a third patient this morning, who I have yet to investigate.  His
mother apparently had Mg problems and was on oral supplements for many
years).

If I cannot maintain serum Mg at a sufficient level top prevent
symptoms on oral supplements, I use self-administered subcutaneous
fluids containing Mg at home.  I have a number of short bowel patients
with electrolyte abnormalities on this regimen (as well as both the
renal leak patients mentioned above) and it has been useful in
preventing symptoms.

Best wishes

Ian

IS Young
Professor of Medicine, Queen's University Belfast
Associate Medical Director (Research and Development), Belfast Health
and Social Care Trust

Wellcome Research Laboratories
Top Floor, Institute of Clinical Science A Block,
Royal Victoria Hospital
Grosvenor Road
Belfast BT12 6BJ
Northern Ireland

tel: 0044 2890 632743
fax: 0044 2890 235900
email: [log in to unmask] 



  ----- Original Message ----- 
  From: Hallworth Mike (RLZ) 
  To: [log in to unmask] 
  Sent: Monday, October 01, 2007 5:15 PM
  Subject: Profound hypomagnesaemia


  Does anyone have any ideas about a 62 year old chap who was found to
be profoundly hypomagnesaemic (Mg<0.2 mmol/L) and hypocalcaemic with low
PTH after a CABG in May, and has kept dropping his magnesium since then?
He was also admitted in 2002 with a hypomagnesaemic/hypocalcaemic
generalized seizure, following a diarrhoeal illness.

  There is no evidence of excessive renal Mg loss (urine Mg 0.4 mmol/L
when serum Mg 0.22 and <0.2 mmol/L when serum 0.3), and the usual
suspects (alcohol, drugs, poor diet) have been excluded. For many years,
he has opened his bowel x3 daily, often with loose stool, and the
gastroenterologists are looking at that, so it may just turn out to be
secondary to abnormal GI loss, but I have been asked about the
possibility of intestinal malabsorption due to mutation of the TRPM6
gene, as seen in familial hypomagnesaemia with secondary hypocalcaemia
(he said, having just looked it up!!). Does anyone have any experience
of this in adults as opposed to infants, or have any other bright ideas?
He is currently being maintained on high dose oral magnesium which isn't
really keeping up (Mg running around 0.5 mmol/L), and obviously isn't
doing much for his loose bowel.

  Thanks 

  Mike 


  ------ACB discussion List Information-------- This is an open
discussion list for the academic and clinical community working in
clinical biochemistry. Please note, archived messages are public and can
be viewed via the internet. Views expressed are those of the individual
and they are responsible for all message content. ACB Web Site
http://www.acb.org.uk List Archives
http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html List
Instructions (How to leave etc.) http://www.jiscmail.ac.uk/ 

------ACB discussion List Information--------
This is an open discussion list for the academic and clinical
community working in clinical biochemistry.
Please note, archived messages are public and can be viewed
via the internet. Views expressed are those of the individual and
they are responsible for all message content.
ACB Web Site
http://www.acb.org.uk 
List Archives
http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html 
List Instructions (How to leave etc.)
http://www.jiscmail.ac.uk/

**********************************************************************
This email and any files transmitted with it are confidential and intended
solely for the use of the individual or entity to whom they are addressed.
Any views or opinions presented are solely those of the author and do 
not necessarily represent those of East Kent Hospitals NHS Trust.  If
you are not the intended recipient, be advised that you have received
this email in error and that any use, dissemination, forwarding, printing
or copying of this email is strictly prohibited.

If you have received this email in error please notify the system
manager at the following email address: [log in to unmask]

www.kentandmedway.nhs.uk

This footnote also confirms that although this email message has been
swept by MIMEsweeper for the presence of computer viruses, it is strongly 
recommended that you carry out your own virus scan of this
message and any attachments.

www.mimesweeper.com
**********************************************************************

------ACB discussion List Information--------
This is an open discussion list for the academic and clinical
community working in clinical biochemistry.
Please note, archived messages are public and can be viewed
via the internet. Views expressed are those of the individual and
they are responsible for all message content.
ACB Web Site
http://www.acb.org.uk
List Archives
http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html
List Instructions (How to leave etc.)
http://www.jiscmail.ac.uk/

Top of Message | Previous Page | Permalink

JiscMail Tools


RSS Feeds and Sharing


Advanced Options


Archives

March 2024
February 2024
January 2024
December 2023
November 2023
October 2023
September 2023
August 2023
July 2023
June 2023
May 2023
April 2023
March 2023
February 2023
January 2023
December 2022
November 2022
October 2022
September 2022
August 2022
July 2022
June 2022
May 2022
April 2022
March 2022
February 2022
January 2022
December 2021
November 2021
October 2021
September 2021
August 2021
July 2021
June 2021
May 2021
April 2021
March 2021
February 2021
January 2021
December 2020
November 2020
October 2020
September 2020
August 2020
July 2020
June 2020
May 2020
April 2020
March 2020
February 2020
January 2020
December 2019
November 2019
October 2019
September 2019
August 2019
July 2019
June 2019
May 2019
April 2019
March 2019
February 2019
January 2019
December 2018
November 2018
October 2018
September 2018
August 2018
July 2018
June 2018
May 2018
April 2018
March 2018
February 2018
January 2018
December 2017
November 2017
October 2017
September 2017
August 2017
July 2017
June 2017
May 2017
April 2017
March 2017
February 2017
January 2017
December 2016
November 2016
October 2016
September 2016
August 2016
July 2016
June 2016
May 2016
April 2016
March 2016
February 2016
January 2016
December 2015
November 2015
October 2015
September 2015
August 2015
July 2015
June 2015
May 2015
April 2015
March 2015
February 2015
January 2015
December 2014
November 2014
October 2014
September 2014
August 2014
July 2014
June 2014
May 2014
April 2014
March 2014
February 2014
January 2014
December 2013
November 2013
October 2013
September 2013
August 2013
July 2013
June 2013
May 2013
April 2013
March 2013
February 2013
January 2013
December 2012
November 2012
October 2012
September 2012
August 2012
July 2012
June 2012
May 2012
April 2012
March 2012
February 2012
January 2012
December 2011
November 2011
October 2011
September 2011
August 2011
July 2011
June 2011
May 2011
April 2011
March 2011
February 2011
January 2011
December 2010
November 2010
October 2010
September 2010
August 2010
July 2010
June 2010
May 2010
April 2010
March 2010
February 2010
January 2010
December 2009
November 2009
October 2009
September 2009
August 2009
July 2009
June 2009
May 2009
April 2009
March 2009
February 2009
January 2009
December 2008
November 2008
October 2008
September 2008
August 2008
July 2008
June 2008
May 2008
April 2008
March 2008
February 2008
January 2008
December 2007
November 2007
October 2007
September 2007
August 2007
July 2007
June 2007
May 2007
April 2007
March 2007
February 2007
January 2007
2006
2005
2004
2003
2002
2001
2000
1999
1998


JiscMail is a Jisc service.

View our service policies at https://www.jiscmail.ac.uk/policyandsecurity/ and Jisc's privacy policy at https://www.jisc.ac.uk/website/privacy-notice

For help and support help@jisc.ac.uk

Secured by F-Secure Anti-Virus CataList Email List Search Powered by the LISTSERV Email List Manager