Short Course in FBAT/PBAT in Boulder, Colorado
Course Date
October 15-16, 2007
Location
Institute for Behavioral Genetics, University of Colorado; Boulder, CO
Application Dates
Applications will be accepted until September 10, 2007. Once your application is accepted, fees will be collected starting no sooner than August, 2007.
Course Organizers and Faculty
Matt McQueen (Institute for Behavioral Genetics, University of Colorado at Boulder)
Nan Laird (Department of Biostatistics, Harvard School of Public Health)
Christoph Lange (Department of Biostatistics, Harvard School of Public Health)
Description
The increasing availability of genetic marker data, especially SNPs, has made investigations of genetic associations between marker data and disease commonplace. This course will focus on family based designs for association studies; these designs use information on affected individuals and their relatives, most commonly parents and/or siblings. Family based designs are attractive in that they test for both association and linkage thus avoiding difficulties with population stratification and admixture. In addition, the population information in the data can be used for model building and screening. This course will give a very brief introduction to the basic concepts of genetic association in general, and family based designs in particular. The focus of the course is on the FBAT/PBAT methodology and how to use the packages. An overview of the topics discussed can be found in Laird NM and Lange C “Family Based Designs in the Age of Large-Scale Gene-Association Studies,
Nature Reviews Genetics, 2006, 7:385-394.
The orientation of the course is practical rather than theoretical. It combines lectures and computer tutorials with hands on data analysis using the FBAT and PBAT packages. Both packages can be accessed from the FBAT/PBAT web pages:
http://www.biostat.harvard.edu/~clange/default.htm
http://www.biostat.harvard.edu/~fbat/default.html
P2BAT is available through the R-package that can be downloaded at
http://www.r-project.org
The GoldenHelix PBAT version will be posted on the course web-page 2 weeks before to the course. A special website will be created for the course so that all course materials will be available there. Note: Both GoldenHelix PBAT and P2BAT will be taught in this course.
Intended audience
This course is intended for clinicians, epidemiologists, data analysts, geneticists, and statisticians involved in the analysis of genetic data. Familiarity with genetic concepts as well as background in basic statistics at the level of linear/logistic regression is highly desirable. Participants are encouraged to bring their own data sets; check the FBAT web page for details on file format. We also strongly recommend that participants read the manuals before attending the course. There will be no computers provided - PLEASE BRING YOUR OWN LAPTOP. Internet access and power supply will be provided.
Application, Registration and Fees
The course fee is $400.00; this covers course materials, coffee breaks, two lunches and a reception. Applicants will be accepted on a first come first serve basis; the course is limited to 40 participants. Full time doctoral students and postdocs may obtain a reduced fee of $150 with a letter certifying student status from your institution. Please fill out the Registration Form (see below) and return via email to Matt McQueen ([log in to unmask]).
Registration Form
(http://ibgwww.colorado.edu/~mcqueenm/BOULDERFBATPBAT_files/FBATPBATinBoulder.doc)
Preliminary Schedule
Monday 10/15
08:00 - 08:30 Registration
08:30 - 10:00 Basic concepts I
10:30 - 10:15 Break
10:30 - 11:15 Basic concepts II
11:15 - 12:15 FBAT computer tutorial/Presentation
12:15 - 13:15 Lunch
13:15 - 14:30 Multiple markers: haplotypes and the multimarker test
14:30 - 15:45 Break
14:45 - 15:30 Complex phenotypes: Multiple Phenotypes and Time to Onset
15:30 - FBAT/PBAT Computer tutorial/Presentation
17:00 R08:30 - 10:00 Screening and model building using the population information
10:00 - 10:15 Break
10:15 - 12:30 PBAT Computer tutorial/ Presentation
12:30 - 13:30 Lunch
13:30 - 15:00 Whole genome scans; screening with trios
15:00 - 15:15 Break
15:15 - 17:00 PBAT Computer tutorial/ Presentation
|