The below project involves a mix of methodological development and data
analysis and would suit a statistician or epidemiologist with strong
quantitative skills. If you would like to discuss the project in
further detail please contact [log in to unmask] Deadline is
14 Sept 2007
John
Relationship between medication error and patient harm due to adverse
drug effects
Background: Several primary care databases have been established in
the United Kingdom that include longitudinal records of morbidity and
drug prescription data on several million people with up to 20 years
follow-up, including The Health Information Network (THIN primary care
dataset), and MediPlus. Quality of data recording by GPs has been
encouraged by the GP contract introduced in 2004 which includes
incentives for coding all consultations, treatments and diagnoses by
READ codes.Ascertainment of drug exposure (except for over-the-counter
preparations) and morbidity can be almost complete. It is possible to
use these databases to detect medication errors and patterns of
non-compliance in patients, and associated patient morbidity such as
increase in adverse drug reactions (ADRs). This project aims to
establish the prevalence and type of medication errors in an adult UK
population using primary care data and two classes of drug (i) statins
(ii) fluoroquinolones, and assess risk arising from medication error in
relation to patient morbidity. Recent relevant publications are given
below:
(1) Dean FB, Vincent C, Schachter M, Barber N. The incidence of
prescribing errors in hospital inpatients: an overview of the research
methods. Drug Saf 2005;28(10):891-900.
(2) Ghaleb MA, Barber N, Franklin BD, Yeung VW, Khaki ZF, Wong IC.
Systematic review of medication errors in pediatric patients. Ann
Pharmacother 2006 October;40(10):1766-76.
Lead supervisor: Dr Mariam Molokhia (LSHTM) [log in to unmask]
Co-supervisors: Professor John Whittaker (LSHTM) , Professor Nick
Barber (School of Pharmacy)
Please be aware that non-EU applicants will be liable for the
difference between home and overseas PhD fees
(http://www.lshtm.ac.uk/prospectus/howto/tuitionfees2007-08.html).
John Whittaker
Professor of Genetic Epidemiology and Statistics
Department of Epidemiology and Population Health
London School of Hygiene & Tropical Medicine
Keppel Street
London WC1E 7HT
[log in to unmask]
Phone: +44 (0)20 7927 2025
Fax : +44 (0)20 7580 6897
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