Previously New Cross poisons unit have provided this assay.
John
>>> Robin Marks <[log in to unmask]> 08/06/2007 15:28:49 >>>
Metformin is an unusual drug in that high concentrations are retained
in the walls of the gastrointestinal tract.
Also, the same blood levels of metformin can lead to different
glucose-lowing effects, according to whether the drug is administered
orally, intravenously, or via the portal vein.
Below is a quote from a very interesting paper to be found at
http://dmd.aspetjournals.org/cgi/content/full/30/8/861
...Despite the similarity in the concentration-time profiles obtained
for different routes of metformin administration, intraduodenal
administration produced larger response than intraportal metformin
infusion, and lowest response was observed following intravenous
administration. This finding indicates that a significant "first-pass"
pharmacodynamic effect, which occurs in the presystemic sites of action
(liver and the gastrointestinal wall), contributes to the overall
glucose-lowering response of metformin. We applied a combined
pharmacokinetic-pharmacodynamic modeling approach to study the nature of
the first-pass pharmacodynamic effect. The observed data were
successfully described by a novel integrated indirect response
pharmacokinetic-pharmacodynamic model that revealed a correlation
between the temporal metformin concentrations that transit the portal
vein and through the gut wall rather than with drug concentrations that
accumulated in the liver and the intestinal wall....
Robin
Dr R.P.M. Marks
Consultant Chemical Pathologist
Pathology
Calderdale Royal Hospital
Halifax
HX3 0PW
-----Original Message-----
From: Clinical biochemistry discussion list
[mailto:[log in to unmask]]On Behalf Of Ian Holbrook
Sent: 08 June 2007 09:53
To: [log in to unmask]
Subject: metformin analysis
Dear all
Is there anyone in the UK who would be able to measure metformin in the
serum from a patient who is currently on our ICU?
Kind regards
Ian
Dr Ian Holbrook
Dept. Clinical Biochemistry
York Hospital
Wigginton Road
York YO31 8HE
UK
01904 725786
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