Hi,
Please see the following reference. Does this answer your query?
http://pubs.acs.org/cgi-bin/abstract.cgi/jacsat/1999/121/i22/abs/ja990340o.html
regards,
gowri.
--
V.S. Gowri,
Ph.D Student,
Prof. N. Srinivasan's Lab,
Molecular Biophysics Unit,
Indian Institute of Science,
Bangalore - 560 012.
Karnataka, India.
Voice: 2293 2837 (Lab)
Email: [log in to unmask], [log in to unmask]
visit: www.sankalpindia.net
=======================================================================================================================
> Dear All,
>
> We have solved a structure that has an intersubunit His-His H-bond
> (ND1---NE2). The protein most likely undergoes conformational changes
> that involve the making and breaking of H-bonds at this interface. In
> all the protein structures I have previously studied I don't recall ever
> seeing such a bond - His-His ring stacking yes, but never H-bonding. I
> was wondering if anyone else had seen this type of interaction and
> whether it had any functional significance. The crystals were grown at
> pH 5.6.
>
> Many thanks
>
> Dave Lawson
>
> -------------------------------
>
> Dr. David M. Lawson
> Biological Chemistry Dept.,
> John Innes Centre,
> Norwich,
> NR4 7UH, UK.
> Tel: +44-(0)1603-450725
> Fax: +44-(0)1603-450018
> Email: [log in to unmask]
> Web: http://www.jic.bbsrc.ac.uk/staff/david-lawson/index.htm
>
>
> --
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