There's also NMP (N-methyl-2-pyrrolidone).
-- Ian
> -----Original Message-----
> From: CCP4 bulletin board [mailto:[log in to unmask]] On
> Behalf Of Green, Todd
> Sent: 22 January 2007 20:40
> To: [log in to unmask]
> Subject: [CCP4BB] crystal friendly solvents that are useful
> for dissolving hydrophobic small molecules?
>
> Hello All,
>
> I am trying to soak some crystals with a small molecule that
> is quite hydrophobic. I am having trouble with solubilty of
> the small molecule. It will dissolve up to about 1 mM in 100
> % DMSO, but precipitates at concentrations of less than 15
> micromolar when the DMSO concentration is below 20 percent in
> my crystal growth solutions(which are peg 4k, low pH, low
> salt). Can anyone suggest solvents other than DMSO which
> might help dissolve the inhibitor and might be somewhat
> friendly to my crystals.
>
> Thanks in advance-
> Todd Green
>
>
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