ALLIANCE FOR HUMAN RESEARCH PROTECTION (AHRP)
Promoting Openness, Full Disclosure, and Accountability
http://www.ahrp.org
FYI
The second in a New York Times series, "Troubled Children" lays bare
psychiatry's essential flaw-it's Achilles' heel. Namely, that
"modern"psychiatry lacks professional legitimacy-lacking as it does
elementary tools of modern medicine.
As Dr. E. Jane Costello, a professor of psychiatry and behavioral sciences
at Duke University, acknowledges: "The system of diagnosis is still 200 to
300 years behind other branches of medicine." Psychiatry also fails to be
guided by an evidence-based positive benefit / risk assessment of its
prescribed treatments.
The article describes the experience of several families who sought help
from state licensed professionals who they believed would provide
professional guidance and medically appropriate care, only to discover
colossal professional incompetence and lack of any scientific empirically
validated diagnoses or effective treatments.
The Times reports: "What followed was a string of office visits with
psychologists, social workers and psychiatrists. Each had an idea about what
was wrong, and a specific diagnosis: "Compulsive tendencies," one said.
"Oppositional defiant disorder," another concluded. Others said "pervasive
developmental disorder," or some combination."
"Paul Williams, 13, has had almost as many psychiatric diagnoses as
birthdays." His mother says ""Basically, they keep throwing things at us,"
she said, "and nothing is really sticking."
"In his short life, Paul has taken antidepressants like Prozac,
antipsychotic drugs used to treat schizophrenia, sleeping pills and
so-called mood stabilizers for bipolar disorder, in so many combinations
that he has become nonchalant about them. "Sometimes they help, sometimes
they don't," he said. "Sometimes they make me feel like another person, like
not normal."
Dr. Costello acknowledged: "On an individual level, for many parents and
families, the experience can be a disaster." But for the pharmaceutical
industry and its paid key opinion leaders in the psychiatric
establishment-who are referred to in the media as "experts"-the process is
enormously profitable. As the Times reports: "Each diagnosis was accompanied
by a different regimen of drug treatments." A diagnosis-no matter how
arbitrary and unsupportable-confers the appearance of legitimacy for
prescribing drugs. The more severe the "diagnosis" the more toxic are the
drugs prescribed.
The Times descriptive survey, provides confirmation for the underlying flaw
currently governing the field of psychiatry and its related mental health
professionals. Psychiatry operates within a framework of pre-Copernican
science when it was believed that the earth is the center of the universe
around which the sun revolves. Thus, psychiatry is welded to the
unsupportable belief that psychopharmacology is the center of its
professional theoretical and practice around which its science must revolve.
Given the absence of scientific evidence of the drugs' safety and
effectiveness in controlled clinical trials, what rationale other than
faith-based pre-Copernican science is driving psychiatry and the New York
Times to continue to cling to faithfully to the drugs-despite documented
evidence of profound neurological, physical, and psychiatric harm that these
drugs are causing? The drugs prescribed for the myriad "diagnoses" including
ADHD, depression, bipolar oppositional defiant disorder, all carry FDA's
most stringent Black Box warnings because they can cause irreversible,
life-threatening harm. However, the aggressive, even illegal marketing of
these drugs has catapulted them into blockbuster profit makers.
The Times' editors have attempted to deflect the unsettling, commercially
negative report by placing a contradictory message under the picture on
front page which states: "Since a diagnosis of bipolar disorder,
Katherine..is taking medicine and doing better in school."
A recent comprehensive report by the American Psychological Association [1]
found: "For most of the disorders reviewed... there are psychosocial
treatments that are solidly grounded in empirical support as stand-alone
treatments. The preponderance of available evidence indicates that
psychosocial treatments are safer than psychoactive medications. Therefore
the working group recommends that in most cases psychosocial interventions
be considered first."
The APA report obliquely notes that treatment decisions do not currently
appear to be guided by best medical practice principles: that is,
psychiatrists fail to balance the anticipated benefits of its
pharmacological treatment with its possible harms. Furthermore, the report
notes, that "safer treatments with demonstrated efficacy should be
considered first before any use of other treatments with less favorable risk
profiles."
American psychiatrists dispense the most toxic drugs in medicine-with the
exception of those used to treat cancer and AIDS-for children who are
erratically "diagnosed" with bipolar disorder without a scientific
rationale. The drugs prescribed, second generation neuroleptics (a.k.a.
'Atypical antipsychotics) include Eli Lilly's drug, Zyprexa, Johnson &
Johnson's drug, Risperdal, and Pfizer's Geodon. The drugs don't merely
induce weight gain, they cause liver damage, diabetes mellitus,
cardiovascular disease, and sudden death. Future generations will look back
in horror at the physicians who prescribed these drugs for
children-disregarding the profound harm they produce.
The rationale given by Dr. Joan Luby, a child psychiatrist, who promotes the
bipolar diagnosis in children-an American aberration in medicine affecting
American children-illustrates the pre-Copernican mind set that psychiatry's
"authorities" cling to. "There's just not much known. That doesn't mean
these drugs aren't effective. We just don't have the studies to show whether
they are safe and effective."
On the contrary, the evidence has shocked even leading
psychopharmacologists.
Dr. Carol Tamminga: "the side effect outcomes are staggering in their
magnitude and extent and demonstrate the significant medication burden for
persons with schizophrenia.Sky-high drug discontinuation rates were seen,
suggesting rampant drug dissatisfaction and inefficacy." [2]
And Dr. Jeffrey Lieberman: "the aggressive marketing of these drugs may have
contributed to this enhanced perception of their effectiveness in the
absence of empirical information." [3]
1. American Psychological Association, Psychopharmacological,
Psychosocial,and Combined Interventions for Childhood Disorders: Evidence
Base, Contextual Factors, and Future Directions, is available at
http://www.apa.org/pi/cyf/childmeds.pdf
2. See: Dr. Carol Tamminga, "Practical Treatment Information for
Schizophrenia" Editorial, American Journal of Psychiatry, April, 2006, vol.
163:563-565
3. Dr. Lieberman is quoted in: The Washington Post: In Antipsychotics, Newer
Isn't Better," by Shankar Vedantam, Oct. 3, 2006- A-1 at:
www.ahrp.org/cms/content/view/353/94
Contact: Vera Hassner Sharav
212-595-8974
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~~~~~~~~~~~~~~~~~~~~
THE NEW YORK TIMES
November 11, 2006
Troubled Children
What's Wrong With a Child? Psychiatrists Often Disagree
By BENEDICT CAREY
http://www.nytimes.com/2006/11/11/health/psychology/11kids.html
Paul Williams, 13, has had almost as many psychiatric diagnoses as
birthdays.
The first psychiatrist he saw, at age 7, decided after a 20-minute visit
that the boy was suffering from depression A grave looking child, quiet and
instinctively suspicious of others, he looked depressed, said his mother,
Kasan Williams. Yet it soon became clear that the boy was too restless, too
explosive, to be suffering from chronic depression.
Paul was a gifted reader, curious, independent. But in fourth grade, after a
screaming match with a school counselor, he walked out of the building and
disappeared, riding the F train for most of the night through Brooklyn,
alone, while his family searched frantically.
It was the second time in two years that he had disappeared for the night,
and his mother was determined to find some answers, some guidance.
What followed was a string of office visits with psychologists, social
workers and psychiatrists. Each had an idea about what was wrong, and a
specific diagnosis: "Compulsive tendencies," one said. "Oppositional defiant
disorder," another concluded. Others said "pervasive developmental
disorder," or some combination.
Each diagnosis was accompanied by a different regimen of drug treatments.
By the time the boy turned 11, Ms. Williams said, the medical record had
taken still another turn - to bipolar disorder - and with it a whole new set
of drug prescriptions. "Basically, they keep throwing things at us," she
said, "and nothing is really sticking."
At a time when increasing numbers of children are being treated for
psychiatric problems, naming those problems remains more an art than a
science. Doctors often disagree about what is wrong.
A child's problems are now routinely given two or more diagnoses at the same
time, like attention deficit and bipolar disorders. And parents of
disruptive children in particular - those who once might have been called
delinquents, or simply "problem children" - say they hear an alphabet soup
of labels that seem to change as often as a child's shoe size.
The confusion is due in part to the patchwork nature of the health care
system, experts say. Child psychiatrists are in desperately short supply,
and family doctors, pediatricians, psychologists and social workers, each
with their own biases, routinely hand out diagnoses.
But there are also deep uncertainties in the field itself. Psychiatrists
have no blood tests or brain scans to diagnose mental disorders. They have
to make judgments, based on interviews and checklists of symptoms. And
unlike most adults, young children are often unable or unwilling to talk
about their symptoms, leaving doctors to rely on observation and information
from parents and teachers.
Children can develop so fast that what looks like attention deficit disorder
in the fall may look like anxiety or nothing at all in the summer. And the
field is fiercely divided over some fundamental questions, most notably
about bipolar disorder, a disease classically defined by moods that zigzag
between periods of exuberance or increased energy and despair. Some experts
say that bipolar disorder is being overdiagnosed, but others say it is too
often missed.
"Psychiatry has made great strides in helping kids manage mental illness,
particularly moderate conditions, but the system of diagnosis is still 200
to 300 years behind other branches of medicine," said Dr. E. Jane Costello,
a professor of psychiatry and behavioral sciences at Duke University. "On an
individual level, for many parents and families, the experience can be a
disaster; we must say that."
For these families, Dr. Costello and other experts say, the search for a
diagnosis is best seen as a process of trial and error that may not end with
a definitive answer.
If a family can find some combination of treatments that help a child
improve, she said, "then the diagnosis may not matter much at all."
A Kaleidoscope of Diagnoses
The most commonly diagnosed mental disorders in younger children include
attention deficit hyperactivity disorder, or A.D.H.D., depression and
anxiety, and oppositional defiant disorder.
All these labels are based primarily on symptom checklists. According to the
American Psychiatric Association's diagnostic manual, for instance,
childhood problems qualify as oppositional defiant disorder if the child
exhibits at least four of eight behavior patterns, including "often loses
temper," "often argues with adults," "is often touchy or easily annoyed by
others" and "is often spiteful or vindictive."
At least six million American children have difficulties that are diagnosed
as serious mental disorders, according to government surveys - a number that
has tripled since the early 1990s. But there is little convincing evidence
that the rates of illness have increased in the past few decades. Rather,
many experts say it is the frequency of diagnosis that is going up, in part
because doctors are more willing to attribute behavior problems to mental
illness, and in part because the public is more aware of childhood mental
disorders.
At the playground, in the gym, standing in line at the grocery store,
parents swap horror stories about diagnoses, medications or special
education classes. Their children are often as fluent in psychiatric jargon
as their mothers and fathers are. "The change in attitude is enormous,"
said Christina Hoven, a psychiatric epidemiologist at Columbia University.
"Not long ago people did all they
could to hide problems like these." Attention deficit disorder is perhaps
the most straightforward diagnosis. Elementary school teachers are often the
ones who first mention it as a possibility, and soon parents are answering
questions from a standard checklist: Does the child have difficulty
sustaining attention, following instructions, listening, organizing tasks?
Does he or she fidget, squirm, impulsively interrupt, leave the classroom?
These behaviors are so common, particularly in boys, that critics question
whether attention disorder is a label too often given to boys being boys.
But most psychiatrists agree that while many youngsters are labeled
unnecessarily, most children identified with attention problems could
benefit from some form of therapy or extra help.
They are less certain about the children - perhaps a quarter of those seen
for mental problems, some experts estimate - who do not fit any one
diagnosis, and who often go for years before receiving a satisfactory label,
if they receive one at all. These youngsters collect labels like passport
stamps, and an increasing number end up with the label Paul Williams
received: bipolar disorder.
An Illness Under Dispute
Until recently, psychiatrists considered bipolar disorder to be all but
nonexistent in children under 18. Today, it is the fastest growing mood
disorder diagnosed in children, featured on the cover of news magazines and
on daytime talk shows like "The Oprah Winfrey Show."
The explosion of interest in bipolar disorder came after the approval of
several drugs, called antipsychotics, or major tranquilizers, for the
short-term treatment of mania in adults. Beginning in the 1990s some
researchers began to argue that bipolar disorder was underdiagnosed in
adults. Soon, several child psychiatrists were arguing that the illness was
more common than previously thought in children too.
Some experts who made those arguments had ties to manufacturers of
antipsychotic drugs, financial interests disclosed in professional journals.
But the message struck a chord, particularly with doctors and parents trying
to manage difficult children.
Parents whose children have been given the label tend to adopt the
psychiatric jargon, using terms like "cycling" and "mania" to describe their
children's behavior. Dozens of them have published books, CDs, or manuals on
how to cope with children who have bipolar disorder. A recent Yale
University analysis of 1.7 million private insurance claims found that
diagnosis rates for bipolar disorder more than doubled among boys ages 7 to
12 from 1995 to 2000, and experts say the rates have only gone up
since then.
Katherine Finn, a 14-year-old who lives in Grand Rapids, Mich., said she was
grateful for the growing awareness of the disease. Possessed by feelings of
worthlessness as early as the fourth grade, Katherine said that by the sixth
grade she "threw my sanity out the window." She became impulsive, loud, and
abrasive, she said, adding, "I would blurt things out in class, I would moo
like a cow, act like a little kid, just say the most random stuff."
A psychiatrist promptly diagnosed the problem as bipolar disorder, after
learning that there was a history of the disease on her mother's side of the
family. Katherine began taking drugs that blunted the extremes in her mood,
and she now is doing well at a new school. "It hit me like a Mack truck when
I heard the diagnosis, but I knew right away it was correct," said her
mother, Kristen Finn, who is writing a book about her experience. Still,
many psychiatrists believe that, although childhood bipolar disorder may be
real in families like the Finns, it is being wildly overdiagnosed.
One of the largest continuing surveys of mental illness in children,
tracking 4,500 children ages 9 to 13, found no cases of full-blown bipolar
disorder and only a few children with the mild flights of excessive energy
that could be considered nascent bipolar disorder - a small fraction of the
1 percent or so some psychiatrists say may suffer from the disease.
Moreover, the symptoms diagnosed as bipolar disorder in children often bear
little resemblance to those in adults. Instead, the children's moods seem to
flip on and off like a stoplight throughout the day, and their upswings
often look to some psychiatrists more like extreme agitation than euphoria.
"The question with these kids is whether what we're seeing is a form of
mania, or whether it's extreme anger due to something else," said Dr.
Gregory Fritz, medical director of the Bradley Hospital, a psychiatric
clinic for children in Providence, R.I.
Dr. Ellen Leibenluft, a research psychiatrist at the National Institute of
Mental Health, argues that children who are receiving a diagnosis of bipolar
disorder fall into two broad groups. The children in one group, a minority,
have mood cycles similar to those of adults with bipolar disorder, complete
with grandiose moods, and a high likelihood of having a family history of
the illness. Those in the other group have severe problems regulating their
moods and little family history, and may have some other psychiatric
disorder instead.
"It is a mistake to lump them all together and assume they are all the
same," Dr. Leibenluft said. "It may be that the disorder has different
dimensions and looks different in different kids." For parents with a child
who is frantic and possibly dangerous, these distinctions may be academic.
The medications may blunt their child's extreme behavior, which may be all
the confirmation they need.
For others, though, the uncertainties about childhood bipolar disorder loom
larger. They wonder whether mania really explains what their child is going
through, and if not, what it is that is being treated. Evelyn Chase of
Richmond, Va., said that a neurologist drove home his diagnosis of bipolar
disorder in her 10-year-old son by pulling out "a copy of Time magazine and
slamming the article in front of me." Ms. Chase said her son seemed to react
most strongly to abrupt changes in the environment and to certain dyes and
chemicals. "I used the bipolar diagnosis for school and getting services,
but I don't think it covers his behaviors," she said.
For Paul Williams, the diagnosis simply feels like a temporary stop. In his
short life, Paul has taken antidepressants like Prozac, antipsychotic drugs
used to treat schizophrenia, sleeping pills and so-called mood stabilizers
for bipolar disorder, in so many combinations that he has become nonchalant
about them. "Sometimes they help, sometimes they don't," he said. "Sometimes
they make me feel like another person, like not normal."
In recent months, his mother said, Paul seems to have improved: he visibly
tries to control himself when he is upset and usually succeeds. He is an
eager Mets fan who loves reading Harry Potter and the Goosebumps series. He
gets out and plays baseball and football, like any 13-year-old boy.
But he has grown tired of telling his story to doctors, and neither he nor
his mother expect that bipolar disorder will be the last diagnosis they
hear.
In Search of Clarity
The specialists who manage children's psychiatric disorders are trying to
bring more standards and clarity to the field. Harvard researchers are
completing the most comprehensive nationwide survey of mental illness in
minors and hope to publish a report next year. And a recent issue of the
journal Child and Adolescent Psychology was entirely devoted to the subject
of basing diagnoses in hard evidence.
Given the controversies, one of the articles concludes, "we acknowledge that
tackling the issue may be tantamount to taking on a 900-pound gorilla while
still wrestling with a very large alligator." Dr. Darrel Regier of the
American Psychiatric Association, who is coordinating work on the next
edition of the association's diagnostic manual for mental disorders, due out
in 2011, said that researchers would focus on drawing distinctions among
several childhood disorders, including bipolar disorder and attention
deficit disorder. "We wouldn't disagree that criteria for these disorders
currently overlap to
some degree," Dr. Regier wrote in an e-mail message, "and that a significant
amount of research is under way to disentangle the disorders in order to
support more specific treatment indications."
Until that happens, parents with very difficult children are left to read
the often conflicting signals given by doctors and other mental health
professionals. If they are lucky, they may find a specialist who listens
carefully and has the sensitivity to understand their child and their
family.
In dozens of interviews, parents of troubled children said that they had
searched for months and sometimes years to find the right therapist. "The
point is that not everything is A.D.H.D., not everything is bipolar, and it
doesn't happen like you see in the movies," said Dr. Carolyn King,
who treats children in community clinics around Detroit, and has a private
practice in the nearby suburb of Grosse Pointe Farms.
"Kids often have very subtle symptoms they can mask for short periods of
time," Dr. King said, "and the most important thing is to observe them
closely, and get a complete history, starting from birth and straight
through every single developmental milestone." She added, "A speech delay
can look like anxiety," an obsessive private ritual like mania.
Or struggling children, in the end, may look only like themselves, with a
unique combination of behaviors that defy any single label. Camille Evans, a
mother in Brooklyn whose son's illness was tagged with a half-dozen
different diagnoses in the last several years, said she concluded, after
seeing several psychiatrists, that the boy's silences and learning
difficulties were best understood as a mild form of autism "That's the
diagnosis that I think fits him best, and I've just about heard them all,"
Ms. Evans said. The label is not perfect, she said, but it is more specific
than "developmental delay" - one diagnosis they heard - and does not prime
him for aggressive treatment with drugs like attention deficit disorder or
bipolar disorder would. He has not responded well to the drugs he has tried.
"Most important for me," Ms. Evans said, "the diagnosis gives him access to
other things, like speech therapy, occupational therapy and attention from a
neurologist. And for now it seems to be moving him in the right direction."
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