Dear Colleages,
When troponin assay were introduced various times of 6, 8 or 10 hours
were suggested to "rule out" an AMI (ESC/ACC definition of AMI). Since
the "early days" of troponin most manufactuers have introduced much more
sensitive assays for troponin. Does anyone have data or references that
suggest whether it is possible to use earlier time points to "rule-out"
AMI with these assays. For example can a negative result at 4 or 5 hours
after admission make a later rise very unlikely? As a related matter
does anyone have data for the newer troponin assays showing positives in
AMI earlier than the 4 - 6 hour window of the original assays.
If people wish to reply to me directly I will summarise the results but
replies to the mailbase would also be appreciated.
Many thanks,
Graham
Graham Jones
Staff Specialist in Chemical Pathology
St Vincent's Hospital, Sydney
Ph: (02) 8382-9160
Fax: (02) 8382-2489
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