many thanks to your answers; here is the updated list of drugs or other
products that can cause false positive immunoassay results for opiates:
- quinolones,
- rifampicine,
- poppy seeds,
- doxylamine,
- perazine,
+ perhaps other molecules that Nils could, if you please, indicate when you
receive the full text of the latest reference you mention
unfortunately, I won't be able to go to Chicago!
Dr Joseph Watine, PH, AIHP, PharmD, AAHU, EurClinChem
Laboratoire de Biologie Polyvalente
Centre Hospitalier Général
12027 Rodez Cedex 9
France
>From: Nils Tryding <[log in to unmask]>
>Reply-To: Nils Tryding <[log in to unmask]>
>To: [log in to unmask]
>Subject: Re: false positive results for urine opiates
>Date: Mon, 3 Jul 2006 10:22:52 +0200
>
>Thank you for your letter Joseph
>I have not received the complete text yet
>If you will you go to the AACC Chicago meeting in the end of July we can
>meet there
>Kind regards
>Nils
> > yes nils, it does interest me
> >
> > many thanks
> >
> > Dr Joseph Watine, PH, AIHP, PharmD, AAHU, EurClinChem
> > Laboratoire de Biologie Polyvalente
> > Centre Hospitalier Général
> > 12027 Rodez Cedex 9
> > France
> >
> >
> >>From: "Nils Tryding" <[log in to unmask]>
> >>Reply-To: [log in to unmask]
> >>To: "Joseph WATINE" <[log in to unmask]>
> >>Subject: Re: false positive results for urine opiates
> >>Date: Fri, 30 Jun 2006 15:58:12 +0200 (CEST)
> >>
> >>Yes Joseph you are wright.
> >>Perhaps this recent article might interest you
> >>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=abstract&list_uids=16776640&query_hl=18&itool=pubmed_docsum
> >>Hypothesis on interferences in kinetic interaction of microparticles in
> >>solution (KIMS) technology.
> >>
> >>Giovanni ND, Fucci N.
> >>
> >>1. Istituto di Medicina Legale e delle Assicurazioni, Universita
> >> Cattolica
> >>del Sacro Cuore, Rome, Italy.
> >>
> >>The present paper describes an evaluation of the interferences found
>with
> >>an immunochemical drug test performed during a workplace control. During
> >>the period 1993-2003 more than 200,000 urine samples from workers were
> >>examined by the Italian Air Force. Samples were screened for drugs of
> >>abuse (opiates, cocaine, cannabinoids, amphetamines, methadone) using an
> >>immunochemical technique (Roche, kinetic interaction of microparticles
>in
> >>solution, KIMS). A total of 520 positive samples were sent to the
> >> Forensic
> >>Toxicology Laboratory for confirmation by gas chromatography/mass
> >>spectrometry (GC/MS). Approximately 39% of these were found to be true
> >>positives. For the remaining samples, pharmacological therapy in
>subjects
> >>was estimated to evaluate possible interferences due to medicine intake.
> >>Our study showed a high frequency of false-positive results with this
> >>immunochemical technique, mainly for the cannabinoid and amphetamine
> >>groups. Recurrent references to some medicines during subject anamnesis
> >>were noted. Clin Chem Lab Med 2006;44;894-7.
> >>
> >>Nils
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