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ACB-CLIN-CHEM-GEN  2006

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Subject:

Re: Carboxy haemoglobin

From:

Reynolds Tim <[log in to unmask]>

Reply-To:

Reynolds Tim <[log in to unmask]>

Date:

Tue, 21 Mar 2006 08:12:37 -0000

Content-Type:

text/plain

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Parts/Attachments

text/plain (163 lines)

Degradation of aspartame also releases CO. But you need to drink rather
a lot of Diet Coke to make a significant amount - the water toxicity
would probably get you first!


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Prof. Tim Reynolds,
Queen's Hospital,
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work tel: 01283 511511 ext. 4035
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-----Original Message-----
From: Clinical biochemistry discussion list
[mailto:[log in to unmask]] On Behalf Of Trevor Walmsley
Sent: 20 March 2006 21:20
To: [log in to unmask]
Subject: Re: Carboxy haemoglobin


Hi Derek

The only in vivo source of carbon monoxide in the body is in the
degradation of haem when 1 molecule of carbon monoxide is release when
the haem ring opens to form 1 molecule of biliverdin.
http://www.porphyrin.net/Heme_iron/degradation/twosteps.html

This mechanism is responsible for the low levels seen in patients who
are not exposed to carbon monoxide (<1.5%).

Patients with high red cell turnover have corresponding high CO levels.

kind regards 

Trevor Walmsley


"A normal person is one that has not been fully investigated"

Trevor Walmsley, Canterbury Health Labs, Christchurch, New Zealand.
Phone: (0064 3) 364 0326 Fax:Phone: (0064 3) 364 0320 
eMail: [log in to unmask]
Internet: http://www.cdhb.govt.nz/chlabs/staff/trevorw.htm

>>> "Pledger, Derek" <[log in to unmask]> 21/3/06
4:04  >>>
Does anyone have a feel for the highest CoHb level likely to be seen in
patient with no obvious exposure to CO other than from cigarette smoking
(approx. 30/day)? COHb consistently in 12-14% range on 4 occasions now.
Domestic gas appliances and car exhaust OK apparently.  Patient also has
polycythaemia (Hb at diagnosis 19.7, now declining with recurrent
venesection) and COPD.  

Derek Pledger

Dept Clinical Biochemistry
Ipswich Hospital NHS Trust
Heath Road
Ipswich 
IP1 4NS


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