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Subject:

Re: eGFR-

From:

Bartlett Bill <[log in to unmask]>

Reply-To:

Bartlett Bill <[log in to unmask]>

Date:

Wed, 19 Apr 2006 10:50:20 +0100

Content-Type:

text/plain

Parts/Attachments:

Parts/Attachments

text/plain (222 lines)

 Dennis is correct in stating that the original paper of 1999, and the
abstract  describing the modified/abbreviated  4 variable MDRD
equations did not identify the ethnicity factor as specifically relating
to African Americans. In a recent  Clinical Chemistry article, co
authored by Levey, (Clinical Chemistry 52:15-18 (2006), Recommendations
for Improving Serum Creatinine Measurement: A Report from the Laboratory
Working Group of the National Kidney Disease, Education Program) it is
however more  specifically stated that the  modifier applies to African
Americans.

Hope this helps.

Regards

Bill




-----Original Message-----
From: Clinical biochemistry discussion list
[mailto:[log in to unmask]] On Behalf Of Dennis Wright
Sent: 12 April 2006 15:22
To: [log in to unmask]
Subject: Re: eGFR-

Paul,

Unlike the other people who have privately responded to my question you
also work in an area where non Caucasian ethnicity is in the majority,
or at least not insignificant.

I make no assumption regarding surname and colour/ethnicity (the MDRD
paper talks about Blacks not African Americans) as the number of mixed
colour relationships in this locality makes any prediction unsafe.

As regards the PGP I can't help, we got rid of ours and plan to do the
calculation within Cerner Millennium, there is a calculation routine
developed in the States available from the Cerner User Mailbase.

Regards

Dennis

Dr Dennis Wright
Consultant Biochemist/ HOD
Clinical Biochemistry
The North West London Hospitals NHS Trust

-----Original Message-----
From: Paul Eldridge [mailto:[log in to unmask]]
Sent: 12 April 2006 15:04
To: [log in to unmask]; Dennis Wright
Subject: Re: eGFR-

Dennis
You are lucky but check your data quality.
Our PIMS system sends down ethnic group data to Telepath - how do you
handle such ethnic groups as 'British' with obviously non Caucasian
surnames and forenames.
We intend to do single calculation and advise on correction to be
applied if black African or African-Carribean.
Mixed races - VERY difficult.

Help please from others.
We have been trying to set up the calculation in our PGP V5 interface
system for some months as seemed easier than in the Telepath2000 LIMS.
Still not working and not sure why. Any ideas or suggestions ?
Paul

Dr Paul Eldridge

University Hospital Lewisham
London SE13 6LH
UK
Phone: (44) 020 8333 3255
Mobile: (44) 07768 376 775
Fax:      (44) 020 8690 8891

>>> Dennis Wright <[log in to unmask]> 12/04/06 13:23:04 >>>
Our Cerner Millennium LIMS is populated from our PAS with a field
denoting a patient's ethnicity; the potential options are tabulated
below. I assume the phrase African-Caribbean in the DH documents map to
options 3 and 4, and common sense says also to option 5. 

 

Is there any guidance or informed view as to how we should handle the
mixed ethnic group options, i.e does a mixed - white/ black African have
the ethnicity correction of 1.21 applied (or even potentially apply a
correction halfway between 1.21 and 1.00!)

 

Other - Any Other

Asian - Bangladeshi

Black - African

Black - Caribbean

Black - Any Other Background

Other - Chinese

Asian - Indian

Not Given or Not Known

Asian - Pakistani

White - British

Asian - Any Other Background

Mixed - Any Other

Mixed - White/Asian

Mixed - White/Black African

Mixed - White/Black Caribbean

White - Any Other Background

White - Irish

 

Happy Easter

 

 

Dr Dennis Wright

Consultant Biochemist

The North West London Hospitals NHS Trust

 


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