Hello Mohmed,
melaninuria (also known as melanogenuria or melanuria) causes by melanoma
is a cause of urine turning 'as dark-brown as Porter beer' on standing; see
http://www.ulb.ac.be/medecine/loce/espcr/journals/sbornik/melano.htm
'More than 130 years ago, in 1858. a Czech physician Bohumil (Theophil)
Eiselt (1831-1908) described s.c. melanogenuria, i.e. the excretion of s.c.
melanogen, colorless precursor of the dark pigment melanin, in the urine of
three patients with generalized melanoma (23) (fig. 1). He wrote: "Der Urin,
frisch gelassen, war hoch gelb, volkommen klar; bei längeren Stehen wurde er
so dunkelbraun wie Porterbier". So, already at that time, Eiselt recognized
correctly that colorless precursor and not the dark pigment melanin itself
was excreted....
Dr R.P.M. Marks
Consultant Chemical Pathologist
Pathology
Calderdale Royal Hospital
Halifax
HX3 0PW
-----Original Message-----
From: Mohmed Ashmaig [mailto:[log in to unmask]]
Sent: 11 January 2005 22:17
To: [log in to unmask]
Subject: Alkaptonuria????
Dear All,
65 years old patient, his normal yellow looking urine
turned to dark-black colour on standing at room
temperature. The questions are:
1- Alkaptonuria, could be the only possible cause??
2- Alkaptonuria, is it likely to be at this age??
3- What is the minimum time required for the
homogentisic acid to turn the urine to dark colour??
4- Do we need to confirm the diagnosis at this stage
or what?? or what you recommend at this stage.
Thank you for your comment
Mohmed Ashmaig
USA
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