Dear Colleagues,
I would like advice on a patient with markedly elevated CSF protein (11
g/L) with consistent CSF albumin (5 g/L) in a patient with a clinical
diagnosis of Guillain-Barre syndrome. There is no free haem and very little
red cell precipitate after spinning. There is no evidence of blockage on
spinal CT scanning. I am pretty sure that the protein is coming from the
serum following a breakdown on the permeability of the blood-brain barrier.
Also the levels have risen further since a previous sample 2 1/2 weeks ago
(CSF protein 7g/L) in spite of clinical improvement. Can anyone offer
advice of diagnoses other than Guillain-Barre that may cause this pattern,
or is this consistent with this diagnosis.
Many thanks,
Graham
Dr Graham Jones
Staff Specialist in Chemical Pathology
St Vincent's Hospital, Sydney
Ph: (02) 8382-9160
Fax: (02) 8382-2489
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