Dear all,
Two PhD studentships are available in the Department of Chemistry,
Cambridge University commencing October 2005 in the groups of Dr David
Klenerman and Dr Liming Ying. The projects are aimed to exploit the
applications of new biophysical methods we have developed recently: two
colour single molecule fluorescence (PNAS 2004, 101, 14425-14430),
controlled delivery of biomolecules from a nanopipette in solution (Anal.
Chem. 2002, 74, 1380-1385), scanning ion conductance microscopy (JACS
2003, 125, 9834-9839) and an electric-field driven two colour DNA switch
(Angew. Chem. Int. Ed. 2004, 43, 5926-5930). Both projects use ultra-
sensitive fluorescence detection. The first project is aimed to develop
nanoprobe sensors of local pH and other surface properties using the
nanopipette and use these for high resolution mapping of surfaces and
ultimately living cells. The second project aims to construct a
controllable nanoengine which uses a catalytic DNA hairpin as the moving
part, a single-strand DNA/RNA chimera as the fuel and a nanopipette as the
fuel jet.
Applicants should have a good honours degree (at least II.1 or equivalent)
in chemistry or physics, with an interest in biophysical methods or
bionanotechnology. Full funding (fees and maintenance) is available to UK
citizens, and fees only awards are available to other EU citizens.
Applications should include a CV and the names and addresses of two
referees, and should be sent to Dr David Klenerman, Department of
Chemistry, Lensfield Road, Cambridge, CB2 1EW (email: [log in to unmask])
or Dr Liming Ying ( email [log in to unmask]) at the same address. The
closing date for applications is January 31, 2005.
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