I have a fairly complicated design and have some questions about setting it up in
FSL. I have 8 subjects, scanned twice, some of whom are on medication or not (fixed
variable A) and some of whom carry a genetic risk factor (random variable B). Would
it be correct to run a two sample paired t-test with this population but if so how do I
model the other two variables, medication and genetic factor. Or would it be more
correct to model this as a mixed effects anova in FSL? I thought that if I treat time as
a third variable then I'm losing the power of modeling the contrast as a paired t-test
(since the same subjects are scanned twice). I'm looking for theoretical input, not
necessarily the design written out in full. Thanks for your time!
Alison Clements Burggren, Ph.D.
UCLA Brain Mapping Center