--- "Dunn Matthew Dr. (RJC) ACCIDENT & EMERGENCY -
SwarkHosp-TR" <[log in to unmask]> wrote:
> This is the problem with the great majority of
> studies on treatments for
> cardiac arrest: ROSC or survival to hospital
> admission is taken as an end
> point. I appreciate that the numbers required to
> look at neurologically
> acceptable discharge from hospital need to be
> considerably larger, but ROSC
> can just mean a prolonged, expensive and unpleasant
> death and as such is an
> adverse event in some patients rather than a
> sensible proxy.
The problem with using neurologically intact survival
to discharge is that it depends on so many other
things. Optimum intensive care being a major factor.
You could assume that all patients receive the best
care post arrest, but that is a very big assumption!
This makes designing such studies very difficult! It
is not surprising people opt for less challenging end
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