Howdy All,
When segmenting a T1 brain with severe WM disease, i.e. lots of T2
hyperintensities, using FAST with no priors, I'm getting a lot of
misclassification of gray and white matter. In particular, a significant
amount of gray matter is being classified as white. WM signal
hyperintensities appear grayish in T1 images, so I would expect that I
should have more misclassification of white as gray as oppose to gray as
white.
My observations runs counter to my intuition which makes me question what I
am doing and possibly my usage of FAST. Has anyone else observed this issue?
If so, is there something obvious that I am doing wrong. For the record, I
am segmenting T1 images with the default settings for FAST using no priors.
I also have FLAIRs (T2s with CSF appearing dark) which gives me a reference
of the severity of WM hyperintensities. T1s that do not have a significant
amount of WM hyperintensities, i.e. percentage volume of WM signal
hyperintensities to white matter is roughly less than 10%, segment properly.
Any help would be much appreciated. Thank you in advance.
Cheers,
Hoang Tran
Neurobehavioral Research, Inc.
201 Tamal Vista Blvd.
Corte Madera, California 94925
415.927.6627 (Office)
415-924-2903 (Fax)
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