Paul Collinson wrote;
> Beacuse it is a useless test for detecting low vitamin D. An audit of
> 2 years
> work at SGH shows the AUC by ROC analysis to .55 = toss a coin
> Paul Collinson
Was that audit of P-ALP against serum Vitamin D concentration, or P-ALP
against some clinical or biological measure of clinical vitamin D
Ian Godber wrote:
> Of cause it also depends on your cut offs. An audit on nearly 700
> patients carried out when I was in Nottingham (ACB Focus Proc 2001
> p39) resulted in similar findings, although we were testing the
> hypothesis as to whether hypocalcaemia, raised PTH (>30 ng/L) and ALP
> (>280 U/L) could be used as a surrogate measure of Vit D, in the
> investigation of deficiency/insufficiency.
> Our findings showed that this test combination couldn't be used, as
> 19% of subjects would be missed if Vit D insufficiency was defined as
> <30 nmol/L and 11% would be missed if a Vit D of <22 nmol/L was used
I think I'm asking if serum Vitamin D concentration (? on a single
occasion, ? without regard to time of year) is a good enough way of
estimating Vitamin D status and the biological effects of deficiency...
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