>Date: Mon, 02 Dec 2002 18:25:32 -0800
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>From: Linda Holland <[log in to unmask]>
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>Subject: postdoc in devo-evo
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>Postdoctoral position in evolution of developmental mechanisms
>
>Three-year postdoctoral position at University of California San Diego,
>Department of Scripps Institution of Oceanography, La Jolla, CA, USA to
>study the evolution of cis-regulatory elements of the engrailed gene in
>relation to the evolution of body plans using the invertebrate chordate
>amphioxus (Branchiostoma) as a proxy for the ancestral vertebrate.
>Amphioxus is vertebrate-like but lacks the extensive gene duplications
>characteristic of vertebrates. Thus, developmental gene cascades in
>amphioxus are similar to those in vertebrates, but less complex and easier
>to study. An understanding of the evolution of cis-regulation of engrailed
>will provide insights into the ancestral roles of engrailed in development,
>in particular, and the evolutionary conservation of the roles of
>developmental genes versus their co-option for new roles in newly evolved
>structures, in general. To test hypotheses regarding the ancestral role(s)
>of engrailed in development, this study involves expressing amphioxus
>engrailed reporter constructs in amphioxus, a tunicate (Ciona), the
>zebrafish, Drosophila, and the lamprey and comparative experiments with the
>mouse engrailed-2 and Ciona engrailed. Blocking and overexpression studies
>will test the function of the engrailed gene in amphioxus. Applicants with
>backgrounds in developmental genetics and experience in transgenic
>experiments in one or more of these 5 organisms preferred. PhD is required
>for starting date of February 1, 2003. Interested applicants please submit
>a curriculum vitae, names, addresses and e-mail addresses for three
>references to Dr. Linda Z. Holland, Marine Biology Research Division,
>Scripps Institution of Oceanography, University of California San Diego, La
>Jolla CA, 92093-0202 (tel 858-534-5283; fax 858-534-7313; email
>[log in to unmask]).
>
>
>
>Linda Holland
>Marine Biology Research Division
>Scripps Institution of Oceanography
>University of California San Diego
>La Jolla, CA 92093-0202 USA
>Tel. (858) 534-5283
>Fax. (858) 534-7313
>http://Hollandlab.ucsd.edu/intro.htm
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