As far as I am aware there is no link between SHBG and inflammatory
processes.
I agree an SHBG of 421 nmol/L is exttremely high. Could this be due to a
combination of haemochromatosis and cirrhosis(seeJCEM 69 110-6 1989)
Mike Wallace
Glasgow Royal Infirmary
>From: Chris Florkowski <[log in to unmask]>
>Reply-To: Chris Florkowski <[log in to unmask]>
>To: [log in to unmask]
>Subject: A record high SHBG ?
>Date: Wed, 30 Oct 2002 15:18:20 +1300
>
>20 year old male with rheumatoid arthritis and primary hypogonadism.
>Moderately high ethanol intake and smokes marijuana.
>
>Last total testosterone (prior to a testosterone implant) was 22nmol/l
>(normal 9-38) with sex-hormone-binding-globulin (SHBG) of 421 nmol/l
>(normal 9-60 nmol/l) measured by in-house ELISA giving free androgen
>index of 52 (normal >400).
>
>We are aware of a link between ethanol and elevated SHBG but not to
>this degree. We wonder aboout a possible inflammatory mechanism,
>although would welcome any thoughts or feedback.
>
>Dr Chris Florkowski
>Christchurch, New Zealand
>
>
>
>
>
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