Frank:
Thanks for the response. My understanding is that Merk is switching from an
animal derivative for Dex. They evidently just stopped making it and have not
ramped up production of the non-amimal version yet and it is unclear when it
will be available.
"Underwood, Frank" wrote:
> I'm not convinced that betamethasone sodium phosphate IF in the form of
> Celestone is the best choice as a substitute for dexamethasone sodium
> phosphate (DmNaP). Celestone is a suspension, right? Suspensions typically
> don't work well for ionotphoresis because of the size of the molecules in
> suspension.
>
> Other drugs similar to DmNaP include prednisolone sodium phosphate
> (Hydeltrasol) (should also dissociate two protons from the hydroxyl groups
> on the phosphate, just as DmNaP) and hydrocortisone sodium phosphate
> (Hydrocortone) (same rationale). These are both short acting steroids, just
> as DmNaP, and should have similar effects. The molecular structure is
> similar as well, so should become mono- and di-anionic in solution, so
> should be placed under the cathode for iontophoresis.
>
> Does anyone know why there is a shortage of DmNaP?
>
> Frank Underwood
>
> -----Original Message-----
> From: Graham [mailto:[log in to unmask]]
> Sent: Tuesday, April 24, 2001 10:51 PM
> To: [log in to unmask]
> Subject: Re: Dexamethasone - Iontophoresis
>
> The pharmacist at my hospital suggested Betamethasone. I do not have info on
> its electrical charge yet. I think there was a trial with hydrocortisone
> mixed in with ultrasound gel so you could do phonophoresis instead. I'll see
> if I can get hold of that info.
>
> Graham Wilson
>
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******************************************************
Douglas M. White, PT, OCS
Physical Therapist, Consultant
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