BIOLOGICAL MOLECULES IN THE GAS PHASE

June 10-15, 2001
Connecticut College
New London, Connecticut

HOW TO REGISTER:

Application forms for the Gordon Conference must be submitted to the GRC
Office, P.O. Box 984, West Kingston, RI 02892-0984.  Tel. 401-783-4011 (-
7644 fax).  ONLINE APPLICATIONS ARE ENCOURAGED. These can be accomplished
by accessing this meeting program at the GRC WEBSITE: www.grc.uri.edu ,
selecting 2001 meetings and clicking on <Biological Molecules in the Gas
Phase>.  Click on the application icon at the end of the program.  Please
plan to apply by April 20, 2001 if possible. Thanks

SUMMARY:

This is the inaugural conference in the emerging area of biological
molecules in the gas phase.  Dramatic technological advances both in
experimental and computational methodology have allowed us to begin to
interrogate large molecules of biological significance in a solvent free
environment.  The goal of the conference is to provide the latest research
from the leading groups across the entire field, including spectroscopy,
mass spectrometry and theory.  Results will be presented that span
molecular biology, from smaller model systems to true giants like the
chaperone Gro EL.  The importance of solvation will be emphasized and a
featured lecture will be given by a leading solution biochemist.  We hope
you are as excited about this new research area as we are and invite you to
participate in this ground breaking inaugural Gordon Research Conference.
Chairs: Michael T. Bowers ([log in to unmask]) and Martin F. Jarrold
([log in to unmask]).


========================================================
Program at a Glance

Sunday Evening:  “Spectroscopy”
Don Levy/David Pratt and Rainer Weinkauf

Monday Morning:  “Sequencing”
Mike Gross/Vicki Wysocki, Roman Zubarev and Scott McLuckey

Monday Evening:  “Folding”
Mattanjah deVries/Martin Jarrold , Teresa Head-Gordon and (TBA)

Tuesday Morning:  “Assemblies”
Ken Standing/Jack Beauchamp,Carol Robinson and Joe Loo

Tuesday Evening:  “Hydration and Photochemistry
Charles Desfrancois/ John Simons and  Todd Martinez

Wednesday Morning:  “New Faces”
David Clemmer/Mary Rodgers, Seong Kim, John Klassen and Albert Heck

Wednesday Evening:  “Reactivity”
Evan Williams/Hilkka Kenttamaa and Robert Hettich

Thursday Morning:  “Theory”
Joshua Jortner/Benny Gerber, David Dixon and Martin Karplus

Thursday Evening:  “Featured Lecture”
Michael Bowers/Paul Kebarle

There will be three poster sessions.  Please submit poster titles and
abstracts to Martin Jarrold at the email address above when you apply for
attendance at the meeting.

==========================================================

Detailed Program

Sunday, June 10, 2001

 Reception 4:30 – 6:00 p.m.

 Dinner 6:00 – 7:00 p.m.

Oral Session 1: 7:30 p.m.

 SPECTROSCOPY: Session Chair, Don Levy, University of Chicago

 David Pratt, University of Pittsburgh
 “High Resolution Spectroscopy in the Gas Phase:  Connections to
Biology?”

 Rainer Weinkauf, University of Deusseldorf, Germany
 “Can Gas Phase Spectroscopy Provide Predictions for Solution”

Monday, June 11, 2001

Oral Session 2: 9:00 a.m.

 SEQUENCING: Session Chair, Mike Gross, Washington University

 Vicki Wysocki, University of Arizona
 “The Influence of Peptide Conformation on Dissociation and H/D
Exchange
 Patterns”

 Roman Zuberov, University of Southern Denmark
 “Beyond Electron Capture Dissociation”

 Scott McLuckey, Purdue University
 “Unimolecular and Bimolecular Reactions of Multiply-Charged
Biopolymers
 in a Quadrapole Ion Trap”

Poster Session 1: 4:30 – 6:00 p.m.

Oral Session 3: 7:30 p.m.

 FOLDING: Session Chair, Mattanjah deVries, University of California
at
 Santa Barbara

 Martin Jarrold, Northwestern University
 “Protein Folding in the Gas Phase”

 Teresa Head-Gordon, Lawrence Berkeley National Laboratory
 “Matching Simulation and Experiment of Minimalist Models for
 Annotating Whole Genomes”

Poster Session 1 continued:   9:30 – 11:00 p.m.

Tuesday, June 12, 2001

Oral Session 4: 9:00 a.m.
           ASSEMBLIES:  Session Chair, Ken Standing, University of
Manitoba,
 Canada
            Jack Beauchamp, California Institute of Technology
          "Non Covalent Complexes of Biological Molecules:  Gas Phase and
Solution
           Studies of Reagents that Selectively Bind to Specific Amino
Acids in

 Carol Robinson, Oxford University, UK
 “Gas Phase Dissociation of Macromolecular Particles”

 Joe Loo, Pfizer Corporation, Ann Arbor, Michigan
 “Mass Spectrometry of Protein-Ligand Complexes: More Than Just a
Pretty Picture”


First Principles

Poster Session 2: 4:30 – 6:00 p.m.

Oral Session 5: 7:30 p.m.

 HYDRATION AND  PHOTOCHEMISTRY: Session Chair, Charles
Desfrancois,        University of Paris
             John Simons, Oxford University, UK
 “Hydrated Clusters of Small Biomolecules:  Limpets, Daisey Chains
and Rings”

 Todd Martinez, University of Illinois
 Photoinduced cis-trans Isomerization: Insights for Photobiology
from
 First Principles




Poster Session 2: 9:30 – 11:00 p.m.

Wednesday, June 13, 2001

Oral Session 6: 9:00 a.m.

 NEW FACES:  Session Chair, David Clemmer, Indiana University

 Mary Rodgers, Wayne State University, Detroit, Michigan
 “Towards the Understanding of Metal Ion-DNA Interactions”

 Seong Keun Kim, Seoul National University, Korea
 “Photoionization Study of DNA Bases, Amino Acids and Their Clusters”

 John Klassen, University of Alberta, Canada
 “Decomposition Pathways, Kinetics and Energetics of Gaseous Protein
 Complexes”

 Albert Heck, Utrecht University, Netherlands
 “Assembly and Disassembly of Protein Complexes in Solution and in
the Gas Phase”

Poster Session 3: 4:30 – 6:00 p.m.

Oral Session 7: 7:30 p.m.

 REACTIVITY:  Session Chair, Evan Williams, University of California
at
 Berkeley

 Hilkka Kenttamaa, Purdue University
 “Gas Phase Studies of Radical Reactions of Biomolecules”

 Robert Hettich, Oak Ridge National Laboratory
 “Investigation of Transition Metal Ion Binding to Small
Oligionucleotides
 by MALDI-FTMS”

Poster Session 3 continued:    9:30 – 11:00 p.m.

Thursday, June 14, 2001

Oral Session 8: 9:00 a.m.

 THEORY:  Session Chair, Joshua Jortner, Tel Aviv University

 Martin Karplus, Harvard University
 “Proteins in Solution and in Vacuum: What Do We Know”

 David Dixon, Pacific Northwest National Laboratory
 “Predicting the Properties of Biomolecules from High-Level
Electronic
 Structure Calculations”

 Benny Gerber, Hebrew University, Jerusalem, Israel
 “Vibrational Spectroscopy, Dynamics and the Development of New Force
 Fields for Biological Molecules”

Oral Session 9: 8:00 p.m.

 FEATURED LECTURE:  Session Chair, Michael T. Bowers, University of
 California at Santa Barbara

 Paul Kebarle, University of Alberta, Canada
 “Ion-Water and Ion-Ligand Bond Energies Determined in the Gas Phase
and
 Their Application to Biochemistry and Bio-Analytical Mass
Spectrometry”

===========================================================

sent by:
Mattanjah S. de Vries.
[log in to unmask]