You did not give your address. Anyway, did you repeat the thyroid
results ?
The testosterone result is explained by the raised SHBG. The raised SHBG
is the culprit here. Clinical status of the thyroid? Either you can
rerun/send the sample to the lab using different methology for thyroid
function tests are the usual Ist line option to rule out interference.
Regards
Vivek
Guy's & St.Thomas'
On Fri, 19 Jan 2001 [log in to unmask] wrote:
> We recently came across a male in his 50s seen by the Rheumatologists for
> osteoarthritis and chondrocalcinosis with the following Endocrine results:
>
> Free T4 8.8 pmol/L (10-25)
> TSH 2.1 mIU/L (0.2 - 4.0)
>
> Upon which the following was added in the laboratory:
> Testosterone 41.7 pmol/L (8.0-27)
>
> A repeat sample showed the following:
> Testosterone > 50.0 pmol/L
> SHBG 180 nmol/L (15-55)
> Oestradiol 232 pmol/L (<150) (Extraction method)
>
> Medication: metformin, gliclazide, acarbose, phenytoin, diltiazem, folic
> acid, coproxamol, losec and zopiclone.
>
> Any thoughts about the possible reasons for the high SHBG would be
> appreciated. Associations with diabetes / metformin and epilepsy have been
> described, but 180 nmol/l is particularly high.
>
> Kind regards
> Marieke Jordaan
>
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