Dear Roger,
There are several reasons why there is no need for AST as cardiac marcer today.
please see http://www.svls.se/sektioner/sfkk/keynumb/eng_index.htm
With kind regards
Nils
"Bertholf, Roger" wrote:
> Dear Louise:
>
> I should think that the absence of any mention of AST in the two documents
> you cite would be evidence enough. When I teach medical technology students
> about markers of cardiac ischemia, I mention AST only because it still
> appears, I am told, on the ASCP certifying examination. Until your message,
> I hadn't heard of any laboratories that still used it. Very few labs still
> use LD1/LD2 ratio, which was a standard component of cardiac enzyme profiles
> for many years before being largely replaced by troponins. The obsolescence
> of AST in the diagnosis of MI is mentioned in Tietz's Textbook of Clinical
> Chemistry (3rd Ed) and in Henry's Clinical Diagnosis and Management by
> Laboratory Methods (20th Ed). Perhaps these references will help.
>
> Kind regards,
>
> Roger
>
> Roger L. Bertholf, Ph.D.
> Associate Professor of Pathology
> Director of Clinical Chemistry & Toxicology
> University of Florida Health Science Center/Jacksonville
>
> > -----Original Message-----
> > From: Louise Tilbrook [mailto:[log in to unmask]]
> > Sent: Friday, November 16, 2001 8:41 AM
> > To: [log in to unmask]
> > Subject: AST and cardiac markers
> >
> >
> > Apologies if this has been raised before. I want to drop AST
> > from our "cardiac markers" profile - can anyone point me in
> > the direction of any useful evidence to quote to my clinical
> > colleagues regarding its lack of utility in diagnosing AMI. I
> > tried the recent consensus paper in Eur Heart J and the NACB
> > recommendations in Clin Chem 1999 - but neither mentions AST!
> > Thanks for your help
> > Louise Tilbrook
> >
> > Louise Tilbrook
> > Principal Clinical Scientist
> > Pathology Department
> > Princess Alexandra Hospital
> > Hamstel Rd
> > Harlow
> > Essex
> > CM20 1QX
> > Tel: 01279 827034
> > Fax: 01279 416846
> > [log in to unmask]
> >
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