CENTRE FOR MEDICAL STATISTICS
SEMINAR SERIES on BIOSTATISTICS 2000/2001
NO 1: Wednesday, November 29th, 2000, at 2:30 pm
Can We Define and Detect Gene-Gene, Gene-Environment and
Gene-Treatment Interactions?
by
Professor David Clayton
(Wellcome Trust Principle Research Fellow
Department of Medical Genetics
University of Cambridge)
There is a widespread assumption that recent advances in mapping
the human genome will have profound implications for epidemiology
and for therapeutic research, and that this will largely be achieved
through the identification of "interaction". In epidemiology, it is a
rare grant application which does not highlight the possibilities for
the study of "gene-environment interaction". Yet such claims rarely
define the notion with any precision, or discuss the manner in which
statistical interaction relates to interaction in the mechanistic sense
understood by biologists.
This paper will review the various ways in which interaction arises in
statistical analysis of genetic epidemiological studies, and discusses
the implications for study design.
All welcome!!
Venue:
The Art Gallery
Chancellor's Building
Keele University
http://www.keele.ac.uk
http://www.keele.ac.uk/depts/ma/seminars/medstats.html
http://www.keele.ac.uk/university/campus/maps/
____________________________
Janet Drewery
Secretary
Centre for Medical Statistics
Keele University
Staffordshire ST5 5BG
England
Email: [log in to unmask]
Tel: (01782) 583269
Fax: (01782) 583269/584268
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