We perform the measurement of CDT by IEF-immunofixation. Unfortunately, the
technique is too long and insensitive to detect concentrations observed in
CSF...
F. Cotton
----- Original Message -----
From: Prof. O. Zinder <[log in to unmask]>
To: <[log in to unmask]>
Sent: Sunday, July 16, 2000 4:50 PM
Subject: CSF leakage
>
> The measurement of iso-transferrin is indeed the best method to detect CSF
> as opposed to other fluids.
> The test, however, is not trivial, is based on iso-electric focussing, and
> requires well-trained personnel. I do not believe it can be used as a
> screening test.
>
> However there is an advantage in placing this test on the menu, since
> besides its proven ability to discern CSF, it has also been shown to be
> present in alcoholic subjects and has been used to define these
individuals
> as alcoholics, and also has the ability to detect complex carbohydrate
> defect syndrome (CDGS) in glycoproteins which result in severe metabolic
> diseases.
>
> Oren Zinder
> Prof. Oren Zinder
> Department of Clinical Biochemistry
> Rambam Medical Center
> Haifa, ISRAEL 31096
> Tel: +972-4-854-3767
> Fax: +972-4-854-2409
> email: [log in to unmask]
> [log in to unmask]
>
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