Methods for the detection of cryoglobulin are not particularly advanced.
We have been looking at trying to make the method less subjective by
measuring absorbance change upon warming up serum/plasma, with some
success. Has anyone used a similar or other approach to reducing the
subjectivity of cryoglobulin detection.
P.S. If a sample is stored at 4 degrees C and mixed before examination,
we have noticed that chylomicrons appear to give a turbidity to the
specimen that disappears on re-heating. In extreme cases it would be
possible for this to cause false positive results for cryoglobulin with
inexperienced analysts.
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