>Lars Breimer wrote:
>Obviously BSA measurement date from the Great War, not just before WWII as
I suspected. Were the authors American -- most likely -- or French or even
>French Canadians? Was it a new way of calculating the dose of poison gas?
The rationale for always adjusting GFR to body surface area apparently dates
back to the 19th century when the 'law of surface area' was used in
physiology and medicine to calculate fluid and drug requirements.(1) In the
middle of the 20th century, the application of BSA formulae to urea
clearance seemed to give children and adults comparable numerical values,(2)
and since then the utilisation of this adjustment has fallen, largely
unquestioned, into common use.
1. White AJ, Strydom WJ. Normalisation of glomerular filtration rate
measurements. Eur J Nuclear Med 1991; 18: 385-90.
2. McCance RA, Widdowson EM. The correct physiological basis on which to
compare infant and adult renal function. Lancet 1952; ii 860-2.
(taken from the exquisite prose (!) in Kilpatrick ES, Keevil BG, Addison
GM. Does adjustment of GFR to extracellular fluid volume improve the
clinical utility of cystatin C? Archives of Disease in Childhood 2000; 82:
>Les Culank wrote
> Not an answer to your question, but you may find interest & perhaps
> from reading the much-quoted Dubois+Dubois 1916 paper, Arch Intern Med vol
> 17, p 863
In fact, according to the Ciba Geigy books this formula, which is in common
use, is based on only 9 (yes, nine) subjects. So much for evidence based