This may be somethng similar
Domain swapping of a llama VHH domain builds a crystal-wide beta-sheet
structure.
Spinelli S, Desmyter A, Frenken L, Verrips T, Tegoni M, Cambillau C.
FEBS Lett. 2004 Apr 23;564(1-2):35-40.
Remy Loris
Vrije Universiteit Brussel
On 18/06/12 15:49, anna anna wrote:
> Hi all!
> I'd like your opinion about a structure I solved.
> Apart from protein structure itself, I think that my protein xtallized
> in an odd way!
> The biological unit is a dimer while the asymmetric unit is a tetramer
> (red cartoon in the figure) resulting from domain swapping between two
> dimers.
> The strange thing is that swapping connects infinite monomers and,
> rather than a xtal, my diffracting object seems a multilayer of
> endless linear polymers, a kind of papyrus with greek fret-like
> fibers. The figure shows the orientation of the polymers in each layer.
> I'd like to know if some of you have already seen a similar pattern or
> it is weird as I think!
> I'm further racking my brain to figure out a biological implication of
> this behaviour, I thought something like plaque formation but I can't
> find support in literature.
>
> All suggestions are welcome!!
>
> Cheers,
> Anna
>
>
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