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The holy LR is a vast step forwars in understanding tests- BUT when combining sens and spec into ONE measure- we lose information. E.g. at times having a test with high specificity is very important, whereas at other times high sensitivity is the thing you want. Also, and quite disheartening: A sens 40% and spec 98% => LR+ =20 and B sens 80% and spec 96% => LR+ =20 and C sens 100% and spec 95% => LR+ = 20 A, B and C should generate very different test interpretations ******************************************************************* Atle Klovning, MD, Research Fellow, Specialist in General Practice/Family Medicine Div. for General Practice, University of Bergen, Norway (+47) 55 58 67 09 (+47) 55 58 67 10 (FAX) http://www.uib.no/isf/people/atle/ ******************************************************************* %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%