Hi world: I was posed the question below. Opinions are solicited. Thank you in advance. one of my outpatient staff has a referral to deliver iontophoresis to an exquisitely tender xiphoid process. No history of trauma, but the xiphoid is out of alignment and there is a real mechanical provocation with strong abdominal contractions and deep inspiration. Therapist has ruled out cardiac etiology. The patient has already been treated with systemic prednisone to no benefit. Apparently the internist has asked for an orthopedic injection but no one has agreed to inject. we cant find anything to date in the literature that says ionto is contraindicated, but so far everyone she talks to offers hesitancy to go ahead and treat with ionto by virtue of site.