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I used to have a reference for this, but the rule of thumb is that the upper limit of the 95% confidence interval is 3/n, i.e. 3/8 for 3 patients. Mark Mark Ebell, MD, MS Department of Family Practice Michigan State University [log in to unmask] Helping Physicians Become Medical Information Masters http://www.infopoems.com > -----Original Message----- > From: Malcolm Daniel [SMTP:[log in to unmask]] > Sent: Thursday, July 22, 1999 3:42 AM > To: 'Paul Sullivan'; ebm group > Subject: RE: Proportion of zero > > Instead of using the calculations ( which in this case give you a standard > error of zero), access the Geigy tables. You should be able to find them > in the reference section of your library. Turn to page 89 and you will > find the "Exact Confidence Limits". In the of none of 8, the 95%CI > range from 0% to 33.6%. > > Cheers > > Malcolm > > -----Original Message----- > From: Paul Sullivan [SMTP:[log in to unmask]] > Sent: 22 July 1999 08:12 > To: ebm group > Subject: Proportion of zero > > Can any one help? I'm struggling with the technical point of how to deal > with a proportion of zero, > especially in a small study. e.g. "none of the eight study patients > responded to treatment therefore the treatment > should never be used clinically for similar patients". > Is there a way of generating a confidence interval for a proportion of > zero? %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%