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Andrew Jull writes: >a colleague and I are engaged in systematic reviews and >are likely to encounter cross-over trials; neither of us >are very familar with this methodology and would >appreciate a good article on appraising cross-over >trials. Does anybody have such a reference? While it does not talk about appraising per se, you can get a better appreciation of cross-over designs by reading chapter 5 of "Medical Uses of Statistics". Bailar, John C. III and Mosteller, Frederick, ed. (1992) Medical Uses of Statistics, 2nd Edition. Boston MA: New England Journal of Medicine Books (ISBN: 0-910133-36-0). Steve Simon, [log in to unmask], Standard Disclaimer. STATS - Steve's Attempt to Teach Statistics: http://www.cmh.edu/stats %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%