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I am hoping for a little statistical guidance with the 95% CI around an NNT. Here are the specifics I am working with: The CER is 0.8, the EER is 0.585, so the ARR is 0.215. The CI around the ARR is -0.00256 to 0.433. So far this makes sense to me. Now, the NNT = 4.65, but taking 1/ARR for the confidence limits, I get a 95% CI on my NNT of -390 to 2.3. This doesn't even include my value of 4.65, and doesn't intuitively make sense. What am I doing wrong? Julie Brown, MD Pediatric Emergency Medicine Fellow, box CH-04 Children's Hospital and Regional Medical Center Seattle, WA 98105 e-mail: [log in to unmask] fax: 206 527 3892 %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%