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Dear all I'm in the process of doing some power calculations for a trial (comparing GP led nursing home admission with emergency hospital admission for the elderly). The main outcome measures I'd like to consider are the Barthel index (a measure of independence) and the Euroquol-5QD quality of life measures (incorporating 5 indices). Does anybody have any suggestions for levels of differences in these outcomes for the two arms of the trial that are clinically significant/important/worth being able to find and justifications for these levels? Does anybody have any references for data regarding variability (as in SD) of Euroquol-5QD scores in the elderly. I have some empirical evidence for the Barthel index from a study which found an SD of about 3. I won't have a useful baseline as the patients will all be admitted acutely. I have investigated the links of QOL measures on A Booth's lists but couldn't find anything detailed enough I'd be very grateful for pointers Cheers Owen Dempsey GP/erstwhile HSResearcher %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%